https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834185/ … Video phenotypic screens for neuroactive drugs in zebrafish; in broad strokes, zebrafish behavior responds to drugs in "predictable" directions. Stimulants speed up motion, anxiolytics slow it down.
Phenotypic screening picks up some drugs that are bioactive in vivo but not in vitro; i.e. it avoids false negatives from in-vitro screening.
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Out of a 14,000 drug library, 7% caused a change in behavioral barcode with a z-score > 5. Authors don't say how many of these are known neuroactive drugs in mammals.
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Bottom line is that this is evidence video-based, behavioral phenotypic screening adds value. Recapitulates stuff we know from independent sources (similar chemical structures) and adds stuff we don't (bioactivity).
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