The life-extension-skeptical theory I find most credible is "there is no conserved metabolic pathway governing lifespan that can be altered without serious harm to the organism. Aging is just overall damage/entropy; there is no "master switch" regulating its rate."
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1/4 (Twitter's algo changed (again). Tweet sequences often drop some for some readers. I see 5 tweets from you ~linearly responding to my question.) It sounds like there's actually kind of a lot of pragmatically different "master switch hypotheses" to group into families.
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2/4 One family is that there is a {highly, moderately, non} conserved master switch up-regulated by {some dose} of an {existing, not-yet-existing} {druggable,biologic} drug. (Maybe call this the "pillable" family and define the master switch to be touchable by a "pillable"?)
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