The life-extension-skeptical theory I find most credible is "there is no conserved metabolic pathway governing lifespan that can be altered without serious harm to the organism. Aging is just overall damage/entropy; there is no "master switch" regulating its rate."
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"test existing drugs and see what works" is *so* much easier than actually developing novel technology and understanding of aging biology, and it might not be enough, but it's silly not to do it first in case the problem is actually that easy.
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1/4 (Twitter's algo changed (again). Tweet sequences often drop some for some readers. I see 5 tweets from you ~linearly responding to my question.) It sounds like there's actually kind of a lot of pragmatically different "master switch hypotheses" to group into families.
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for instance: developing gene editing to the point that it's less error-prone & more effective at transfection; learning how to "reprogram" cells to stemness without risking cancer; learning how to synthesize organs in the lab; etc. True innovation.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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