This was the coolest thing at BAAM. It may have applications beyond Leigh Syndrome, since we all lose mitochondrial function as we age. Knockout of https://en.wikipedia.org/wiki/NDUFS4 causes neural damage. Low oxygen (like at high altitude) rescues normal function & lifespan.https://twitter.com/lifespanscience/status/1105247621872988160 …
Jain said that she tried and failed to treat mitochondrial impairment with a small molecule that targeted Hypoxia-Induced Factor, but then she tried hypoxia itself and it worked.
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Illustrates two broader principles: 1.) don't assume that all the best treatments will be drugs; 2.) a simple solution has fewer places to break than a complex one.
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