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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin 12 Mar 2019
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      Sarah Constantin Retweeted The Longevity Research Institute

      This was the coolest thing at BAAM. It may have applications beyond Leigh Syndrome, since we all lose mitochondrial function as we age. Knockout of https://en.wikipedia.org/wiki/NDUFS4  causes neural damage. Low oxygen (like at high altitude) rescues normal function & lifespan.https://twitter.com/lifespanscience/status/1105247621872988160 …

      Sarah Constantin added,

      The Longevity Research Institute @lifespanscience
      Hypoxia completely rescues a mouse model of Leigh syndrome (a mitochondrial disorder). #BAAM19
      1 reply 0 retweets 0 likes
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      Sarah Constantin‏ @s_r_constantin 12 Mar 2019
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      https://jainlabblog.files.wordpress.com/2017/12/pnas_2017.pdf … Isha Jain at UCSF.

      1:58 PM - 12 Mar 2019
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        2. Sarah Constantin‏ @s_r_constantin 12 Mar 2019
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          https://jainlabblog.files.wordpress.com/2017/12/hypoxiatherapy_science_2016.pdf … The hypoxia program allows organisms to survive while consuming less oxygen. Impaired mitochondrial cellular respiration means organisms can get less energy from oxygen. The hypoxic response helps them be "thriftier" with oxygen.

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        3. Sarah Constantin‏ @s_r_constantin 12 Mar 2019
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          Jain said that she tried and failed to treat mitochondrial impairment with a small molecule that targeted Hypoxia-Induced Factor, but then she tried hypoxia itself and it worked.

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        4. Sarah Constantin‏ @s_r_constantin 12 Mar 2019
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          Illustrates two broader principles: 1.) don't assume that all the best treatments will be drugs; 2.) a simple solution has fewer places to break than a complex one.

          0 replies 0 retweets 0 likes
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