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We are excited to share our latest work in the @trompoukilab published by @ImmunityCP . Did you know that the repetitive part of the genome is transcriptionally active and functionally important during endothelial-to-hematopoietic transition?
Our work shows how the embryonic aorta has evolved to utilize repetitive element transcripts to induce innate immune receptor signals and orchestrate developmental hematopoiesis! Nature never maintains anything that is of no use to it.
We cannot help but wonder whether this mechanism can be pertinent to other systems entailing chromatin rearrangement and potential repetitive element activation. There's definitely plenty more where that came from...
@etrompouki thank you for trusting me with this brilliant breakthrough-idea! I was proud to be the first author of this job and I would like to thank all our colleagues and collaborators in, but also out of the @mpi_ie , including @tvbowman22 @MarinaMione @postdocpotts
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