Rob Menzies

@robertmenzies

Drug hunter

   
Vrijeme pridruživanja: studeni 2010.

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    This is why we have Leap Years

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    If you didn't think the biology of and potential for exosomes for diagnosis and therapies was awesome, this review will change your mind by and Valerie LeBleu w/

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    29. sij

    Tremendously excited about our publication today that brings together clinical, in-vivo and in-vitro studies tackling the challenge of through identifying as a potential therapeutic target. Read on (tweetorial)!

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    30. sij

    A prime example of a great explainer for a complex topic: my brilliant friend , aka Gene Editor, explains genome editing and search-and-replace (prime) editing re:

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    23. sij

    Important paper out on via 96% sequence identity to a bat ~80% sequence identity to SARS ~95% AA sequence identity in 7 conserved replicase domains to SARS uses the same cell entry receptor, ACE2, as SARS

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    17. sij

    If more scientists calculated confidence distributions, they would realise that a point estimate is a value in which you have zero confidence.

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  7. 18. sij

    Enjoying this from ⁦⁩ on ⁦⁩. Speaks to my own experience moving from physics and academia into biology and biopharma. Scientific rigor and serendipity are key ingredients in drug discovery

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  8. 12. sij
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    9. sij

    A study of a Finnish sibling pairs with type 1 diabetes aimed at identifying DNA patterns associated with diabetic nephropathy found that the genes encoding two protein kinase C isoforms were the most strongly associated with the condition.

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    9. sij

    Observational studies have long suggested that patients with diabetes have an elevated risk of developing Alzheimer disease and other forms of dementia, and a growing body of evidence suggests that glucose hypometabolism may be a key player in dementia p…

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    8. sij

    Our review of recent past & near future of human disease genetics (1990-2030) has just been published in Nature (). Thanks to co-authors too numerous to list, & to et al at Nature (including the reviewers) for pulling this together. 1/n

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    New and emerging modalities continued to accumulate FDA approvals in 2019, including a first approval for a nanobody and several approved antibody–drug conjugates - find out more here

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    8. sij

    The Piezo ion channels story—how cells sense touch and pressure—is playing out to be much bigger than initially envisioned (including pain and beyond neurons) by w/

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    Helpful discussion on the importance of permeability in targeted protein degradation, based on recent work out of UNC. blog in :

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    How the periodic table was created is a perfect illustration of how science progresses, as we explored on its birthday

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    A paper shows the largest reference phosphoproteome of almost 120,000 human phosphosites. To identify those likely to be critical, researchers used a machine learning approach capable of ranking them according to functional importance.

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    12. pro 2019.

    Check out our **just published** review in We () review how allows us to probe immunity, and the implications this has for 🧬🔥👨‍💻👩‍🔬

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    Platelet activation at the site of vascular injury from our 2018 review on platelets in by Joris Roelofs & colleagues

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