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  1. Prikvačeni tweet
    23. pro 2019.

    ! Have you ever wanted to learn about spatial and non-spatial hippocampal function, especially in primates? We look at single neurons + ensemble activity across tasks during virtual navigation in a new paper with in 1/

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  2. proslijedio/la je Tweet

    Excited to announce our bioRxiv paper describing OpenMonkeyStudio. This is a BIG three-lab project that took a LOT OF people working very hard a lot of time.

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  3. proslijedio/la je Tweet
    15. sij

    See the impressive visualization of 's uncovering of hippocampal subfileds by unfolding and unsupervised clustering of laminar and morphological features in the 3D BigBrain at

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  4. 14. sij
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  5. proslijedio/la je Tweet
    10. sij

    So, in summary our model shows: (i) how gating and inhibition can contribute to memory, (ii) how memory access/availability dynamically change over time, and (iii) how context representations, such as those observed in hippocampus and PFC, may interact with and control memory.

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  6. 7. sij

    Thanks for trusting me to start this line of research, building such an awesome team, and becoming such an important mentor and friend through all of our journeys together!

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  7. proslijedio/la je Tweet
    29. pro 2019.

    Exciting new work from and colleagues showing task-dependent spatial and non-spatial representations in the primate hippocampus.

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  8. proslijedio/la je Tweet

    Neurons in primate non-linearly mix information about space and non-spatial elements of the environment in a task-dependent manner; this efficient code flexibly represents unique perceptual experiences and corresponding memories

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  9. 23. pro 2019.

    There's more to this story that we're still working on, so stay tuned. Cc also 13/

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  10. 23. pro 2019.

    I could never thank my co-authors enough for their work on this. Ben is an incredibly thorough scientist. Guillaume is a programming genius. Lyndon is a mathematical wizard. This couldn't be possible without them, and funding by 12/

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  11. 23. pro 2019.

    So what does this mean for our understanding HPC function? ATM, I believe that neuropsychological theories (memory, space) contain less explanatory power than computational theories (cc ) 11/

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  12. 23. pro 2019.

    We showed that hippocampal neurons could be used to decode space in primates during virtual navigation. However, representation of space is not stable across tasks. Task-specific activity that looks spatial can be tuned to nonspatial parameters that are relevant for behavior. 10/

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  13. 23. pro 2019.

    We found that hippocampal neurons encoded objects, and interaction with context as both perceptual and mnemonic representations. Neural activity could be used to read out specific trial type in the Associative memory task as well. 9/

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  14. 23. pro 2019.

    The lack of stable coding across tasks was striking in the portions of the maze that were especially relevant in the Associative memory task. So, we next examined non-spatial, task-specific activity during the Associative memory task. We looked for perceptual & mnemonic coding 8/

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  15. 23. pro 2019.

    The ensemble could support decoding of position in the maze in each task, but the code for space did not generalize across tasks. There are important nuances and implications here, see the paper for full detail. 7/

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  16. 23. pro 2019.

    Figs 1 & 2 of the paper show single-neuron changes in spatial selectivity across tasks. In Fig. 3, we ask whether coding of spatial position generalized across tasks. 6/

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  17. 23. pro 2019.

    Subjects also completed an Associative memory task in the same environment, which required learning a new set of context-dependent object values every day 5/

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  18. 23. pro 2019.

    One task required just cue-guided navigation, inspired by classic studies of rodents foraging for sugar pellets in an open arena 4/

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  19. 23. pro 2019.

    It's difficult to study spatial and nonspatial activity in single neurons (but see great expts by , , , , ). For a new approach, we trained monkeys to complete two behavioral tasks in a single VR envt. 3/

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  20. 23. pro 2019.

    I started my thesis wanting to study memory in the hippocampus, inspired in part by Brenda Milner & Wilder Penfield. I quickly learned the complexity of this story, with conversation over the primacy of spatial versus non-spatial mnemonic function in the hippocampus 2/

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