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Gilead preparing a trial in China of remdesivir to treat 2019-nCoV: https://www.biocentury.com/article/304364 . Meanwhile, at least 9 trials of #2019-nCoV therapies are underway. https://www.biocentury.com/article/304364 All BioCentury coverage of the outbreak is in front of the paywall at https://www.biocentury.com/coronavirus .pic.twitter.com/MR9Bhpq0Pn
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And here is a sample of 3 policies we describe and how they alter the Reward Box shape and thus the risk and reward of developing particular types of drugs:pic.twitter.com/lJd213pOVo
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Number of patients treated w/ CAR-Ts in Europe (commercial vs academic)
#CART2020pic.twitter.com/TcUOWPCduC
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A prime example of a great explainer for a complex topic: my brilliant friend
@UrnovFyodor, aka Gene Editor, explains#CRISPR genome editing and search-and-replace (prime) editing https://www.nejm.org/doi/full/10.1056/NEJMcibr1914271 … re: https://www.nature.com/articles/s41586-019-1711-4 …@nature@davidrliupic.twitter.com/1lmWsdEVYi
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Matthew Disney is talking about how to approach RNA as a target for small-molecule probes and drugs at
#SLAS2020 - here's a perspective with more on this topic https://rdcu.be/b0VwQ pic.twitter.com/GIjPcQqfuA
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Humira biosimilars now controlling almost 40% of the market in the EU, according to Bernstein. The UK and Germany are outpacing the others... ...and the US looks on in shame, swallowing another 7.4% price increase from AbbVie for 2020pic.twitter.com/zUjbFNQhoa
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Biosimilar competition update:
@pfizer$PFE is launching its 3#oncology#biosimilars at WAC list prices of -22% to -24% below competitors' products https://drugch.nl/2usVtzd#NoTowel Open question: Will#PBMs,#payers, and#wholesalers embrace or block lower price#drugs?Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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The FDA finalized 6 guidance documents on
#GeneTherapy development about: -#Hemophilia -#RareDisease - Retinal disorders - CMC for INDs - LT follow-up - Retrovirus testing Also released new draft guidance on interpreting the sameness of gene therapies.https://www.raps.org/news-and-articles/news-articles/2020/1/fda-finalizes-6-gene-therapy-guidances-unveils-a …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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I can see how this makes it a lot easier to read. Thank you for assembling.https://twitter.com/incub8coalition/status/1221962422359068674 …
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Kobe was a legend on the court and just getting started in what would have been just as meaningful a second act. To lose Gianna is even more heartbreaking to us as parents. Michelle and I send love and prayers to Vanessa and the entire Bryant family on an unthinkable day.
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Given there will be a big need for many biotech's to raise this year & January 2020 broke an all-time record for total amount raised & # of Co's that raised in Jan, I put together a list (far from perfect) of bio companies that have < 2 years of cash based on estimates.
$XBIpic.twitter.com/aAVFILrlsK
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Woodcock to Unger to Stein, or how
$SRPT scored its FDA double play. Via@Vantageanalysishttp://bit.ly/2GcemsvHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Neutrophils as emerging therapeutic targets in infection, pulmonary diseases, cardiovascular diseases, inflammatory disorders and cancer https://go.nature.com/2unacvv - a new review published todaypic.twitter.com/R5LXXQm1dd
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$FTSV Very underwhelming data for anti-CD47 magrolimab + cetuximab combo in colorectal cancer 6.7% (2/30) ORR in KRAS wild type CRC 0% (0/40) ORR in KRAS mutant CRC https://meetinglibrary.asco.org/record/182513/abstract …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Loved this story from
@Jasonmmast -- At#JPM20, two CEOs, two radically different therapies, and a fight to chase down sickle cellhttps://endpts.com/at-jpm20-two-ceos-two-radically-different-therapies-and-a-fight-to-chase-down-sickle-cell/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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$NK Just amazing people are still falling for these "response" from their miracle sextuple combo How the hell do you run a controlled trial to convince FDA about the real effect of your drug?pic.twitter.com/KNmPbZTmjS
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Three important new papers today demonstrate that the presence of B cells in tertiary lymphoid structures (TLS) is associated with a favorable response to cancer
#immunotherapy https://www.nature.com/articles/d41586-019-03943-0 … https://www.nature.com/articles/s41586-019-1922-8 … https://www.nature.com/articles/s41586-019-1906-8 … https://www.nature.com/articles/s41586-019-1914-8 …pic.twitter.com/Adv8biKV4f
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Our NEW Review by Vishwakarma & Piddini
@epiddin discusses how cell competition between tumour cells & neighbouring epithelial host cells may dictate tumorigenesis & proposes manipulating cell competition as an orthogonal therapeutic strategy https://go.nature.com/30m2HAX@NatResCancerpic.twitter.com/pZLlJOfdx9
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This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones http://dlvr.it/RN3LYp pic.twitter.com/iPhO8VcbFr
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