Is it just me or does the soft sweep versus hard sweep distinction seem like relabeling drift and shift? They don’t mean exactly the same thing, but the underlying idea is similar.
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Not sure this is the best analogy. In population genetics, the soft vs hard sweep dichotomy mainly concerns the origin of particular molecular changes post-hoc. drift (in flu speak) could be soft or hard, is typically soft, but one variant eventually takes over.
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Thank you, Richard, for saying this so clearly.
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I remember a paper by Bull and Huelsenbeck looking at how in phage populations recombination is not that necessary to explore combinations of mutations to create alleles, mutation in small genomes and large populations suffice. Careful with generalizations
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Large effective population sizes in RNA virus and small mutation target (genome size) coupled with high mutation rates? One of the main issues of looking at how prevalent are soft vs hard sweeps concerns the possibility of exploring the mutation landscape. (1/2)
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