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Profil korisnika/ce rdhernand
Ryan Hernandez
Ryan Hernandez
Ryan Hernandez
@rdhernand

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Ryan Hernandez

@rdhernand

From busboy and car washer to population geneticist and Director of the Biological and Medical Informatics PhD program @UCSF. Now Assoc. Prof. @McGillGenome.

Vrijeme pridruživanja: rujan 2013.

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    1. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      The increase in NA ancestry in MxAms is consistent across two US cities, and even replicates in an independent sample. The pattern is even apparent across other Hisp/Latinx groups in the US (though sample sizes are small).

      1 reply 1 proslijeđeni tweet 6 korisnika označava da im se sviđa
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    2. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      We spent a LOT of time trying to figure out why NA ancestry has been increasing. TL;DR: it's complicated...! A thread:

      2 proslijeđena tweeta 4 korisnika označavaju da im se sviđa
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    3. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      TBH, going into this project, if anything, I expected NA ancestry to decrease over time. I have one MxAm parent and one EurAm parent. I know lots of others like me, we're admixed!

      1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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    4. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      I have often lived in two worlds. Not as Mexican as my best friend growing up (though my skin was darker), and def not European like some of my other friends (though I knew just as much Spanish as them: 0). But are people like me still rare exceptions in the MxAm community?

      0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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    5. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      I don't know, and that is not what this project is about. But it is why I care about this subject. It's personal.

      0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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    6. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      I see great advances in precision medicine, and I'm super excited! But I also see how biases are creeping in, and how lots of people can be in trouble if we aren't being inclusive and thinking about diversity carefully.

      1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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    7. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      We know demography of US has changed over the 20th century, and by 2044 is predicted to become a ‘minority-majority’ country (where no one racial/ethnic group comprises more than 50% of the population). By 2060 Hisp/Latinx are projected to be the largest ethnicity in the US!

      0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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    8. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      Ryan Hernandez je proslijedio/a tweet korisnika/ceRyan Hernandez

      But, Hisp/Latinx participation in GWAS has continued to hover around 1%. We therefore don't actually know a lot about genetic diversity in Hisp/Latinx populations in the US. (FINALLY, this is starting to change!! https://twitter.com/rdhernand/status/1214784935728431105?s=20 …)

      Ryan Hernandez je dodan/na,

      Ryan Hernandez @rdhernand
      I LOVE that this is a contest: “We confirmed the substantial ancestral diversity of MVP with nearly 30% non-European individuals, surpassing other large biobanks.” There’s the new baseline (note that current US pop is ~40% non-European). https://twitter.com/biorxiv_genetic/status/1214544949779292161 …
      1 reply 1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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    9. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      While there have been a number of amazing papers that have shown there is a lot of genetic diversity across North/South America, we typically assume there is a single NatAm reference panel that can be used for all Hisp/Latinx pops, and show things like this:pic.twitter.com/4HmQS8mctG

      1 reply 0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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    10. Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      This makes us think that Hisp/Latinx pops are largely overlapping in ancestry patterns, and likely have similar patterns of diversity.

      1 reply 0 proslijeđenih tweetova 1 korisnik označava da mu se sviđa
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      Ryan Hernandez‏ @rdhernand 15. sij
      • Prijavi Tweet

      Using UMAP, we find that the story is way more interesting! We present to you, diversity takes flight! Lots more detail in the paper, but the gist is that there is more to the genetic diversity story in Hisp/Latinx pops than 3-way admixture.pic.twitter.com/KpKqDgnw8x

      14:08 - 15. sij 2020.
      • 2 proslijeđena tweeta
      • 18 oznaka „sviđa mi se”
      • Dr. Michael B.C. Rivera Nicolas Bierne 🌱Juan Plants🌱 Federico Sanchez Quinto Xinjun Zhang Michael Hoffman cj battey Tim O'Connor 🇺🇸🇬🇧🇵🇪 JOSE MIGUEL (aka 'Salazar', 'Jeroboam')
      2 proslijeđena tweeta 18 korisnika označava da im se sviđa
        1. Novi razgovor
        2. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          Given that the sample of MxAm was much larger than other Hisp/Latinx pops, we focused on the gradient of NA ancestry in the MxAm "wing":pic.twitter.com/Jt282GhTBV

          1 reply 1 proslijeđeni tweet 4 korisnika označavaju da im se sviđa
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        3. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          We found that if we plot NA ancestry proportions among individuals as a function of their birth year, there was a marked increase! (data on left, zoom on right with same regression line & whiskers but adding 1000 bootstrap loess curves).pic.twitter.com/CUCr3dZ7Un

          1 proslijeđeni tweet 5 korisnika označava da im se sviđa
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        4. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          This change in NA ancestry cannot be explained by any single factor that we thought of. The increase can be partially explained by the joint action of several factors, including subtle shifts in migration & strong effect of ancestry-based assortative mating.

          1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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        5. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          No regions of the genome seem to be associated with increased NA ancestry, but there is a trend of increasing short/medium length ROH on NA ancestry tracts.

          1 reply 1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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        6. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          There is a lot more to explore here! Admixed genomes are amazing! 😍

          1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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        7. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          The observation that NA ancestry is dynamic over very short periods of time has implications for the genetic architecture of complex traits. For example, 22 of the 66 traits we looked at (33%) are statistically correlated with NA ancestry among individuals.pic.twitter.com/hv63NsmIBB

          1 reply 1 proslijeđeni tweet 5 korisnika označava da im se sviđa
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        8. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          We focus on the trait that had the largest effect in our study: height.

          1 reply 0 proslijeđenih tweetova 1 korisnik označava da mu se sviđa
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        9. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          Globally, height has increased due to a variety of non-genetic factors. We find a similar trend in MxAms. When we stratified individuals by quartiles of NA ancestry, we see that all quartiles have increased in height by a similar amount over the ~50yr period investigated.pic.twitter.com/WuKoEcSTHz

          1 reply 4 proslijeđena tweeta 12 korisnika označava da im se sviđa
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        10. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          Height is also one of the most widely studied phenotypes, giving us access to GWAS summary statistics from hundreds of thousands of individuals, and enabling a critical dissection of how well Polygenic Risk Scores (PRS) may fare in MxAm populations.

          1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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        11. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          We found that while the predicted height is weakly correlated with measured height overall, the correlation was primarily driven by the individuals with the lowest NA ancestry: there was no significant correlation for individuals in the top two quartiles of NA ancestry.pic.twitter.com/De6jQFQuzx

          1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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        12. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          This opens up way more questions than we can answer! We hope you enjoy reading this. If you have any comments, please do not hesitate to let us know. We won't be submitting this work for a few days, so help us with some pre-submission peer review!

          1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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        13. Ryan Hernandez‏ @rdhernand 15. sij
          • Prijavi Tweet

          The idea for this project was entirely conceived by @mlspear09, and she deserves all the credit for pulling this together. We had help with replication/graphics/ideas from @adp_diaz/@sfgravel, data help from @ziv_elad, and all around mentorship from @torgerdg.

          0 replies 3 proslijeđena tweeta 10 korisnika označava da im se sviđa
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