Rodrigo Bacigalupe

@rbacigalupe

bioinformatics, microbes and microbiomes. Postdoctoral scientist at VIB-KULeuven Center for Microbiology

Vrijeme pridruživanja: travanj 2014.

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  1. proslijedio/la je Tweet
    4. velj

    Excited to share my first first-author publication as part of my PhD project & working on antimicrobial resistance We compare resistomes between the human mouth and the gut (1/n)

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  2. proslijedio/la je Tweet
    2. velj

    Larger bacterial populations evolve heavier fitness trade-offs and undergo greater ecological specialization

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  3. proslijedio/la je Tweet
    31. sij

    Fine-tuning the effects of dietary on gut microbiota: Chemically modified resistant starches w/ small structural differences induce divergent & highly specific effects on that direct changes in the output of propionate or butyrate

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  4. proslijedio/la je Tweet
    29. sij

    Happy to introduce our new prokaryotic pangenome clustering tool Panaroo! . We show that annotation errors can have a large impact on pangenome inference and that by sharing information between genomes we can correct for this.

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  5. proslijedio/la je Tweet
    16. sij

    Thanks to peer review I'm even more convinced that bacterial species are real biologically meaningful units that exist in nature- "Consistent Metagenome-Derived Metrics Verify and Delineate Bacterial Species Boundaries" out now with new and improved Fig 2:

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  6. proslijedio/la je Tweet
    15. sij

    Today our paper "Harnessing ecological and evolutionary principles to guide the design of microbial production consortia" came out. With and . Free PDF link here (50 d):

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  7. proslijedio/la je Tweet
    14. sij

    Our spiked primer paper is out at ! Useful for RNA viral metagenomic sequencing & assembly - Ebola, Zika, Lassa, etc. Thanks to all for a global collaborative effort!

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  8. proslijedio/la je Tweet
    11. sij

    My first, first author paper is out today🥳! We showed that bacteria tweak expression of horizontally transferred genes through emergence of TF binding sites in their promoters, allowing adaptation to different environments. See

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  9. proslijedio/la je Tweet
    10. sij

    Very cool! In this preprint, authors screened bacteria-free supernatants [...] of over 150 cultured bacterial strains for their effect on colorectal cancer cell growth. Bacteroidaceae, Enterobacteriaceae & Erysipelotrichaceae secretomes ⬆️growth, most Fusobacteriaceae ⬇️ growth

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  10. proslijedio/la je Tweet
    10. sij

    New work from the Typas lab on ‚Collateral damage of antibiotics on gut microbes‘. Finally, a representative overview on the extent by which antibiotics target human gut microbes and induce antibiotic resistance in the human gut, including antidotes.

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  11. proslijedio/la je Tweet
    9. sij

    I’m beyond excited to see our paper out! ‘Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy’ Based on imidazole EPS inhibitors I started developing in 2008 and an inspiring research stay with Kevin Foster

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  12. proslijedio/la je Tweet
    9. sij

    Here's our paper out today! We found 121 host genes that the flu virus needs to replicate itself. About half of them are new discoveries, and might make good therapeutic targets.

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  13. proslijedio/la je Tweet
    9. sij

    New preprint: "Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment" - Here we show how host pressures can lead to increased *susceptibility* to antibiotics. 1/n

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  14. proslijedio/la je Tweet
    6. sij

    Highly parallelized microfluidic droplet cultivation and prioritization on antibiotic producers from complex natural microbial communities | bioRxiv

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  15. proslijedio/la je Tweet
    3. sij

    First output of the year! We used direct WGS & genomic epidemiology approaches to explore the long-term consequences of mass drug administration on Treponema population structure and studied the emergence of the first reported cases of AMR Yaws.

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  16. proslijedio/la je Tweet
    29. pro 2019.

    We revisited the ortholog conjecture, some 10 years after the original paper. Collaboration w/ Moses Stamboulian, , and .

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  17. proslijedio/la je Tweet

    Study of microbial genomes from non-human primates from , and co. They take datasets from 22 species of primate and generate metagenome-assembled genomes. Most are from novel genomes and there is very little overlap with humans

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  18. proslijedio/la je Tweet
    23. pro 2019.

    Excited to announce a new preprint w/ on the ecological and evolutionary responses of the human gut microbiome during antibiotic treatment. . A lot of surprises in here for me -- will post a longer summary after the holidays.

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  19. proslijedio/la je Tweet
    20. pro 2019.

    ReferenceSeeker: rapid determination of appropriate reference genomes.

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  20. proslijedio/la je Tweet

    Strengthening the cell membrane barrier A recent study found that antimicrobial sensing coupled with cell membrane remodelling mediates antimicrobial resistance and virulence in Enterococcus faecalis.

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