Je kan informatie over je locatie aan je Tweets toevoegen, bijvoorbeeld je stad of exacte locatie, via het web en applicaties van derden. Je kan altijd de locatiegeschiedenis van je Tweets verwijderen. Meer informatie
There is no EV-D68 viremia. How virus gets from respiratory tract to CNS is the object of our research. Respiratory tract is innervated, which is one possibility. Or within cells. Please give our grant applications good scores so we can make progress.https://twitter.com/LauringLab/status/1055937296258744320 …
Imamura: EV-D68 NA detected in serum by PCR in 43% of 1-4 yo pts hosp w/ EV-D68 resp infection, most within first 3 days of onset. Suggests EV-D68 may have viremic phase but early after respiratory onset, would be gone by time of neurologic onset. http://bit.ly/2SjxNoa pic.twitter.com/sLfaGbTEuk
Viraemia is seen in some patients - maybe it is more that it is too low level or transient to be useful diagnostically ..but that it could still be an important part of the pathogenesis?
& it could be that the viraemia is mostly well before the neurological presentation. How would we know? We wouldnt see it because we wont have blood specimens from before the neurological presentation.
Interesting. If through nerves would expect only bulbar (cranial nerve) from upper tract or cervical and thoracic spine lesions from lungs. Isolated lower limb paralysis from lumbar lesions harder to explain? Good luck with the grant!
I’m just a parent reading the internet but AFM tends to affect upper extremities/neck more frequently than similar polio which affected lower limbs more often. Is it because EV-D68 is respiratory transmission and polioviruses were fecal-oral route?
Do we know that? Enterovirus viremia is largely understudied.
Olfactory nerve?
Twitter is mogelijk overbelast of ondervindt een tijdelijke onderbreking. Probeer het opnieuw of bekijk de Twitter-status voor meer informatie.
