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profshanecrotty's profile
Prof. Shane Crotty
Prof. Shane Crotty
Prof. Shane Crotty
@profshanecrotty

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Prof. Shane Crotty

@profshanecrotty

Vaccines and immune system scientist. Professor, La Jolla Institute for Immunology (LJI), a non-profit research institute. PhD not MD. Opinion ≠ medical advice

La Jolla, San Diego
lji.org/labs/crotty/
Joined March 2016

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    Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

    Our new paper rapidly studied T cell + antibody immune responses in average COVID-19 cases. This is good news in multiple ways, including coronavirus vaccines. @ljiresearch https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3 …pic.twitter.com/Cg89Sg1mth

    2:54 PM - 14 May 2020
    • 2,268 Retweets
    • 4,546 Likes
    • Monna Käyhkö dohmas qiqenuno Michele Boldrin Lilly Watson BrotyBoy🏴󠁧󠁢󠁳󠁣󠁴󠁿🇮🇹 shahid parwez BAS John Garrett Gretchen Dorn
    132 replies 2,268 retweets 4,546 likes
      1. New conversation
      2. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        This is good news in multiple ways, for coronavirus vaccine development, understanding disease, and even modeling the future course of the pandemic.

        2 replies 42 retweets 295 likes
        Show this thread
      3. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        There has been a huge amount of uncertainty about immunity to SARS2—both in the context of COVID19 disease pathogenesis and in the context of how to develop a good vaccine.

        3 replies 32 retweets 253 likes
        Show this thread
      4. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        In our study, 100% of COVID-19 cases made antibodies. 100% of COVID-19 cases made CD4 T cells. 70% of COVID-19 cases made measurable CD8 T cells. We believe these findings are good news, and consistent with normal antiviral immunity.

        35 replies 631 retweets 1,675 likes
        Show this thread
      5. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. Again, good news.

        2 replies 73 retweets 397 likes
        Show this thread
      6. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        We specifically chose to study people who had an average COVID19 disease course—non-hospitalized—to provide a solid benchmark for what a normal immune response to SARS2 looks like.

        8 replies 66 retweets 439 likes
        Show this thread
      7. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        Additionally, any potential for crossreactive immunity from other coronaviruses has been predicted by epidemiologists to have significant implications for the pandemic going forwards. We detected SARS-CoV-2-reactive CD4+ T cells in ~50% of unexposed individuals.

        16 replies 153 retweets 560 likes
        Show this thread
      8. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        Detecting SARS2-reactive T cells in ~50% of unexposed people suggests cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2. This might influence susceptibility to COVID-19 disease.

        42 replies 204 retweets 671 likes
        Show this thread
      9. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        Crossreactive T cells are also relevant for vaccine development, as cross-reactive immunity could influence responsiveness to candidate vaccines.

        3 replies 42 retweets 303 likes
        Show this thread
      10. Prof. Shane Crotty‏ @profshanecrotty 14 May 2020

        Whether this immunity is relevant in influencing clinical outcomes is unknown, but it is tempting to speculate that the crossreactive CD4+ T cells may be of value in protective immunity, based on SARS and flu data.

        19 replies 82 retweets 404 likes
        Show this thread
      11. Prof. Shane Crotty‏ @profshanecrotty 15 May 2020

        The Supplementary Figures can be found here as a public link. https://www.dropbox.com/s/nbzyucixb1441hj/Supplemental%20Material_CELL.pdf?dl=0 …pic.twitter.com/Jnpiu3btOk

        13 replies 36 retweets 195 likes
        Show this thread
      12. End of conversation

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