I've been calling this the 'massively pleiotropic mutation model' for about 17 years, but whatever. https://www.theatlantic.com/science/archive/2017/06/its-like-all-connected-man/530532/ …
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Its not the same as pleiotropy. The argument isnt that the proteins or genes' direct functions are pleiotropic. Rather they act in concert.
I argued for a many-to-many mapping from genes to traits. Pleiotropic from the genes' viewpoint, polygenic from the traits' viewpoint.
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It's a thing of semantics, tgen, albeit it critical. How direct need an effect be to be pleiotropic? Id argue only direct molecular actions.
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I used the term more in the classical quantitative genetics sense, not the molecular mechanism sense. So,
#semantics
End of conversation
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