No, they're observed regularities. There are 2 kinds of gametes, because isogamy is an unstable equilibrium. https://en.wikipedia.org/wiki/Gamete
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Trans doesn't change which gametes you make, so doesn't change biological sex according to the evolutionary definition.
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Of all these folks with peculiar things to say on sex, I wonder how many could provide an accurate definition of the word
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BREAKING!...
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