In 1,000 years, how many species (significantly distinct, reproductively divergent varieties) of humans, humanoids, post-humans, and/or human-adjacent AIs will there be?
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If we had some super advanced version of CRISPR that allowed radical genetic transformations to be made and unmade that might put an end to the concept of reproductive divergence. You could just get a genetic dongle to interface with that different species, as could the offspring
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