In 1990,Tooby&Cosmides explored evolutionary scenarios, concluded that most heritable variation is likely a noisy concomitant of mutation-selection or pathogen host coevolution. Prediction is: heritability reflects rare genetic variants. Much criticized, now perhaps vindicated.https://twitter.com/NicoleBarbaro/status/1116157606924623879 …
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@LarsPenke@primalpoly have also taken this possibility seriously. Do you gents agree with this interpretation of the finding that the missing heritability apparently reflects small effects of many rare variants?2 replies 0 retweets 2 likesShow this thread
Replying to @SpeciesTypical @LarsPenke
Yes, I think there's a lot of mutation-selection balance driving this heritable variation. Lars may have a different view.
6:51 AM - 11 Apr 2019
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