Genetics question: So, some traits are monogenic, some are super polygenic, many are in between. Is there a theory of why some traits ended up more or less polygenic than others?
The more complex the trait, the more genetic loci it depends on, the easier it is for a wide range of mutations to mess it up, so the more 'polygenic' it appears. That was our logic in this piece on the evolutionary genetics of mental illness: https://www.primalpoly.com/s/2006-genetics-mental-illness.pdf …
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I’d think there are some traits for which smooth variance is beneficial at the population level. Eg the oft mentioned variation of males (altho I think this explanation for greater male variance is overstated)
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What's your definition of a 'complex' trait? Height, for example, seems like a 'simple' trait, and is yet polygenic.
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