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So is there a significantly higher occurrence of Alzheimer's among people with that gene?
Yes, ApoE4 predicts significantly higher Alzheimer's risk https://en.wikipedia.org/wiki/Apolipoprotein_E …
ApoE4 is also associated with high cholesterol. This studied showed that Alzheimer's only affected ApoE4 men whose cholesterol fell many years before symptoms started. The high cholesterol may be protective for those with ApoE4https://www.ncbi.nlm.nih.gov/pubmed/9549720?dopt=Abstract …
But many with this gene do NOT get Alzheimers
APOE 4 is neither necessary nor sufficient to cause AD, but all else being equal, it increases risk by about 10x to have 2 of them.
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