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Seems a horrible candidate for crispr when there are far simpler, more damaging diseases to go after. Why not cystic fibrosis, huntington’s, sickle cell? All monogenetic diseases.
Sickle cell is one where we know the hidden benefit was probably anti-malaria resistance, and we're doing a pretty good job of eliminating malaria from the world.
Yes. Chesterton’s fence probably applies here more than anywhere, and sickle cell is perhaps the one example of a monogenetic disease allele where we can explain the purpose of the fence.
I read that Tay Sachs disease provides some resistance to tuberculosis.
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