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Harvard aims to use CRISPR gene editing to eliminate ApoE4 variant, to reduce Alzheimer's risk. My worry: ApoE4 already spread to 14% of white population, so it can't just be a harmful mutation -- must have had hidden benefits that gene-editing could lose.https://www.technologyreview.com/s/612494/despite-crispr-baby-controversy-harvard-university-will-begin-gene-editing-sperm/ …
For more on the logic of why high-frequency alleles have probably had hidden benefits, see my paper here (Keller & Miller, 2006): https://static1.squarespace.com/static/58e2a71bf7e0ab3ba886cea3/t/58ebee5e5016e1a6e81f6693/1491856998877/2006+genetics+mental+illness.pdf …
E4 has been linked to higher levels of vitamin D, for example.
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