Harvard aims to use CRISPR gene editing to eliminate ApoE4 variant, to reduce Alzheimer's risk. My worry: ApoE4 already spread to 14% of white population, so it can't just be a harmful mutation -- must have had hidden benefits that gene-editing could lose.https://www.technologyreview.com/s/612494/despite-crispr-baby-controversy-harvard-university-will-begin-gene-editing-sperm/ …
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Is that still true if the downside (Alzheimer’s) doesn’t show up until well after age of reproduction (and often after being a grandparent too)?
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