Harvard aims to use CRISPR gene editing to eliminate ApoE4 variant, to reduce Alzheimer's risk. My worry: ApoE4 already spread to 14% of white population, so it can't just be a harmful mutation -- must have had hidden benefits that gene-editing could lose.https://www.technologyreview.com/s/612494/despite-crispr-baby-controversy-harvard-university-will-begin-gene-editing-sperm/ …
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Replying to @primalpoly
Messing with genes seems like a bad idea to me when we know so little about what they do in concert with each other.
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Replying to @IAmNSPetals
This is why I think embryo selection using polygenic scores (across thousands of genetic variants) will give better results than editing individual genetic loci like ApoE.
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