Stress increases glucocorticoids in the brain (cortisol in humans, corticosterone in rodents). Long exposure neurodegenerative effects: mitrochondrial dysfunction, cell atrophy & death, hyperphosphorylation of cytoskeletal Tau protein which is important for dendrite remodeling
So I'd caution against thinking of it too highly as an important explanatory variable.
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Supposedly astrocytes synthesize BDNF, GDNF, and NGF. Maybe damage to astrocytes from cortisol is enough to explain reduction in BDNF, and then {chronic SSRI -> reduced serotonin in PVN thalamus -> reduced cortisol} is enough to restore BDNF levels.
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