Stress increases glucocorticoids in the brain (cortisol in humans, corticosterone in rodents). Long exposure neurodegenerative effects: mitrochondrial dysfunction, cell atrophy & death, hyperphosphorylation of cytoskeletal Tau protein which is important for dendrite remodeling
I'm not sure, but I think that elevated serotonin in the paraventricular nucleus of the hypothalamus leads eventually to the production of glucocorticoids in the adrenal cortex above the adrenal glands, by the kidneys,
-
-
Elevated serotonin, not underproduction, seems to be the problem of mood disorders, although we're really bad at measuring it in the CNS. Acute administration of SSRIs makes it worse. After chronic administration, some compensatory mechanisms must reduce serotonin levels.
-
BDNF is a peptide hormone which acts as a growth factor for neurons. Acute administration of SSRIs like fluoxetine reduces BDNF. This https://www.ncbi.nlm.nih.gov/pubmed/16842762 is the only thing I know about how chronic SSRI administration increases BDNF transcription
- 3 more replies
New conversation -
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.