I'm not sure, but I think that elevated serotonin in the paraventricular nucleus of the hypothalamus leads eventually to the production of glucocorticoids in the adrenal cortex above the adrenal glands, by the kidneys,
Stress increases glucocorticoids in the brain (cortisol in humans, corticosterone in rodents). Long exposure neurodegenerative effects: mitrochondrial dysfunction, cell atrophy & death, hyperphosphorylation of cytoskeletal Tau protein which is important for dendrite remodeling
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Elevated serotonin, not underproduction, seems to be the problem of mood disorders, although we're really bad at measuring it in the CNS. Acute administration of SSRIs makes it worse. After chronic administration, some compensatory mechanisms must reduce serotonin levels.
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