This very interesting paper (text of a lecture) by Walter Fontana that I'm reading is giving me a lovely perspective on what I was driving at in this piece (1/3)https://www.chemistryworld.com/opinion/the-chemical-absurdity-of-molecular-recognition/4010924.article …
See, here's a conventional view of the Wnt/beta-catenin signaling pathway. Note that axin is one of the proteins involved. (2/3)pic.twitter.com/CDiyKBJOgA
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Now here, from Walter's paper, is a representation of most of the protein-protein interactions so far identified that involve axin. In what sense then does the preceding image offer an actual molecular-scale picture? What is "happening" in real time? (3/3 + 1 to come)pic.twitter.com/IEZatQ8BHB
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His conclusion, then, seems very sound to me: "Today, the uniquely difficult challenge of biology is [not quanitification but] representation. To reason about something you first have to represent it somehow."
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