See, here's a conventional view of the Wnt/beta-catenin signaling pathway. Note that axin is one of the proteins involved. (2/3)pic.twitter.com/CDiyKBJOgA
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See, here's a conventional view of the Wnt/beta-catenin signaling pathway. Note that axin is one of the proteins involved. (2/3)pic.twitter.com/CDiyKBJOgA
Now here, from Walter's paper, is a representation of most of the protein-protein interactions so far identified that involve axin. In what sense then does the preceding image offer an actual molecular-scale picture? What is "happening" in real time? (3/3 + 1 to come)pic.twitter.com/IEZatQ8BHB
His conclusion, then, seems very sound to me: "Today, the uniquely difficult challenge of biology is [not quanitification but] representation. To reason about something you first have to represent it somehow."
Can you give the link to the Fontana (lecture) paper, please?
Sorry, I'd like to but I'm not completely sure Walter is ready to make it public yet... I hope he will, it is full of interesting ideas.
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