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pdhsu's profile
Patrick Hsu
Patrick Hsu
Patrick Hsu
@pdhsu

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Patrick Hsu

@pdhsu

biotechnologies, CRISPR, and startups | 🇨🇦 - @harvard - @broadinstitute - @editasmed - @salkinstitute | incoming faculty @BerkeleyBioE fall 2019

patrickhsulab.org
Joined March 2009

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    Patrick Hsu‏ @pdhsu Oct 8

    Title: "Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice" The experiment: "Mice were exposed for 4 h per day and 5 d per week for 54 wk" What would be the ideal methodology? https://www.pnas.org/content/pnas/early/2019/10/01/1911321116.full.pdf …

    10:28 AM - 8 Oct 2019
    • 2 Retweets
    • 16 Likes
    • Mattia Ronin Attorney Ogunmodede O. Samson Galileo Kurian Lab Caleb Lareau Mark Hammond Rohan Arora Alexey Guzey
    4 replies 2 retweets 16 likes
      1. McMasterMBF‏ @RayTruant Oct 8
        Replying to @pdhsu @DocDellaire

        place the mice in a bus shelter.

        0 replies 0 retweets 2 likes
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      1. New conversation
      2. Rohan Arora‏ @rohanarora_ Oct 8
        Replying to @pdhsu

        Would’ve loved to see more justification regarding the exposure time chosen — I don’t think 4 hours of constant exposure limited to 5 days a week is a good model for human smokers — solid paper but as always with mice, lots of questions related to translatability

        1 reply 0 retweets 0 likes
      3. Ogunmodede O. Samson‏ @seyicleo Oct 8
        Replying to @rohanarora_ @pdhsu

        I think the folks behind this basic study may not be concerned with translatabity at this stage. It could just be a mission on possibility confirmation & the biological underpinnings. I'll give them due credits while encouraging more robust, advanved studies to be carried out.

        1 reply 0 retweets 0 likes
      4. Rohan Arora‏ @rohanarora_ Oct 8
        Replying to @seyicleo @pdhsu

        Yes totally agree — would just add that perhaps some kind of justification here could perhaps be a useful starting point for future authors

        0 replies 0 retweets 0 likes
      5. End of conversation
      1. James Howe  🐭‏ @jamesrhowe6 Oct 8
        Replying to @pdhsu

        Seems pretty face valid for most juulers that I know, at least. Two friends of mine had to refill pods once every day or every other, which requires a few hours of puffing at least.

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      1. Alexey Guzey‏ @alexeyguzey 19h19 hours ago
        Replying to @pdhsu

        and they don't even mention this in the abstract! just say "54 weeks"

        0 replies 0 retweets 0 likes
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