Pavitra Muralidhar

@pavitra451

Graduate student in evolutionary biology at Harvard, interested in genetic conflict and sex determination.

Vrijeme pridruživanja: rujan 2016.

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  1. Prikvačeni tweet
    6. lip 2019.

    I'm excited to share my paper on the mating preferences of selfish sex chromosomes, now online at Nature! This will be a short thread on the main results. 1/

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  2. proslijedio/la je Tweet
    24. pro 2019.

    Congratulations to - the well-deserving recipient of the 2019 Sewall Wright Award from the

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  3. proslijedio/la je Tweet
    29. stu 2019.

    Our AAV paper published in Science on Thanksgiving, 4+ years with , , , continuing now at , here’s how: including twists, turns, surprises, and many people to thank along the way!

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  4. proslijedio/la je Tweet
    18. stu 2019.

    New preprint, on how *aggregate* recombination modulates: (a) variance in the genetic relatedness of relatives; (b) how rapidly selection purges introgressed DNA. Turns out (a) and (b) are... related! w/ 1/2

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  5. proslijedio/la je Tweet

    Erin Calfee on admixture and selection in Africanized honey bees: Honey bees not native to Americas - here they are admixed ‘feral’ populations of European origin, and in the 50s African bees were brought over to increase genomic fitness. They escaped!

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  6. proslijedio/la je Tweet
    31. lis 2019.

    Thrilled to have this out- If you want to use QuIBL on your system, please get in touch!

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  7. proslijedio/la je Tweet
    31. lis 2019.

    Our project on genomic architecture, introgression in Heliconius is out! We ( et al) build on work in Heliconius and other systems to show how important hybridization is in evolution. 1/

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  8. proslijedio/la je Tweet
    28. lis 2019.

    Probably the most unexpected discovery of my career: Massive gene amplification on a newly formed Y chromosome! Great teamwork with my lab!

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  9. proslijedio/la je Tweet
    23. lis 2019.

    New preprint, in which we try to understand Fisher's model of sexual selection. With and David Haig.

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  10. proslijedio/la je Tweet
    22. lis 2019.

    (Thread) Here’s my new preprint, with , on genetic privacy in genealogy databases that allow user uploads. (1/n)

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  11. proslijedio/la je Tweet

    "The unifying theme of Hartl’s broad impacts on transmission, population, evolutionary, and medical genetics has been the combination of theoretical insights with cutting-edge experimental techniques."

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  12. proslijedio/la je Tweet
    25. lip 2019.

    In our new paper, just out in PNAS, we derive a surprisingly simple formula that relates the expected diversity of a metastasis to the diversity in the pool of seeding cells. Alex Heyde

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  13. proslijedio/la je Tweet
    15. lip 2019.

    News & Views: Why have females of some species evolved mating preferences for harmful male traits? A Nature paper models how these preferences can evolve if versions of genes that contribute to these traits have beneficial effects when present in females.

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  14. 6. lip 2019.

    For an excellent summary of the paper, please check out the News and Views commentary by Mark Kirkpatrick! 12/

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  15. 6. lip 2019.

    Thank you for reading! Please let me know if you have any questions. 11/11

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  16. 6. lip 2019.

    The picture this theory paints, of one sex chromosome urging its bearer to mate with that individual, the other sex chromosome saying "no, that one!", and the autosomes saying "neither!", reminded me of this wonderful passage from WD Hamilton: 10/

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  17. 6. lip 2019.

    The logic also extends to any genetic element that can influence its host's mating behavior and shows sex-specific or sex-biased transmission—mitochondria, intra-cellular parasites like Wolbachia, and even microbiota are all vulnerable! 9/

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  18. 6. lip 2019.

    I've focused on female mate choice so far, but male mate choice plays an important role in many species! For male mate choice, simply flip the pattern: e.g., a Y chromosome in male mate choice behaves the same as the W in female mate choice. 8/

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  19. 6. lip 2019.

    Z-linked mate preferences for male-beneficial, female-costly traits evolve more readily than X-linked preferences for female-beneficial, male-costly traits, for subtle reasons explained in the paper. So, ZW species are especially prone to selfish sex-linked mate preferences! 7/

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  20. 6. lip 2019.

    This process applies to X and Z chromosomes too! They are sex-biased chromosomes, but not sex-specific like the W. Therefore, their selfish interests are slightly weaker. Note that the X cares more for female fitness (like the W) but the Z cares more for male fitness. 6/

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  21. 6. lip 2019.

    If the W-linked preference is strong enough, its spread eventually causes the trait to become advantageous (its mating advantage exceeding its viability cost). The trait then spreads. This is possible for traits that severely reduce male survival—e.g. by as much as 80%! 5/

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