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We're now used to looking at US covid hotspot maps.
Well, here is one for #Alzheimers.
by @kyleykim @WSJGraphics in https://www.wsj.com/articles/alzheimers-research-looks-at-hot-spots-across-the-u-s-11605558173 … by @clare_ansberrypic.twitter.com/J2s0pupmqI
That is really strange.
particulate pollution builds up the farther you move across the country?
Hypoxyia-inducible factors (HIF-1 and others) are neuroprotective (https://pubmed.ncbi.nlm.nih.gov/28004401/ ) and their expression is induced at high altitudes. It may also be protective from kidney disease. Oxygen is inherently toxic.
Because of its metabolic underpinnings? See diabetes heat map:pic.twitter.com/EwBQmYbHes
Alzheimer’s is being taught as “type 3 diabetes” in many medical programs.https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-is-alzheimers-type-3-diabetes/ …
Looks like population density plus old people moving south in retirement.
glycopvhosphates
I wonder how many of our later life diseases are trade-offs or decisions made via latent evolutionary biological programs triggered by hardship and poverty.
Particulate is a big smoking gun, not sure how it overlaps with this data, though.
@foundmyfitness conversationally blew my mind with this piece yesterday:
Air pollution associated with accumulation of amyloid-beta *in childhood*...https://pubmed.ncbi.nlm.nih.gov/32006765/
Likely. Looking at the map of WA, there are some clear outlier counties where population is a relevant metric. // Makes me wonder about prevailing wisdom around diet. WW county has significant vegetarian population historically but is a hot zone here.
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