"The rising epidemic of obesity in industrialized countries is one of the more common reasons offered for elevated IL-6 levels in otherwise healthy middle-aged adults."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039107/ …
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"The risk of respiratory failure for patients with IL-6 levels of ≥ 80 pg/ml was 22 times higher compared to patients with lower IL-6 levels."https://www.medrxiv.org/content/10.1101/2020.04.01.20047381v2 …
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If that’s the case I wonder if rheumatoid inflammation cascade modulators would be beneficial.
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IL-6 is an inflammatory signaler, this would be true of just about every condition
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specifically IL-6 is what tells your hypothalamus to start a fever
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Is it the cause or the result of the inflammation?
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As a layman this is one of the most insightful things I’ve seen about this disease.
The severe stage is about inflammation.pic.twitter.com/rR5SQMr2Mx
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The figure comes from the following paper that proposes studies should consider the phase of the disease, which makes a lot of sense: https://www.jhltonline.org/article/S1053-2498(20)31473-X/fulltext …
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Interesting thought but it may not be a causal link as I’d imagine being hospitalized for COVID is psychologically stressfulpic.twitter.com/KxTYVNV5bw
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IL-6 levels depend on genetics, right? What factors might affect IL-6 production at the cellular level?
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