Nominating cofounder conflict for #3
The #1 cause of startup death is making something no one wants. The #2 cause is spending too much. Those two account for so many deaths that I'm not even sure what #3 is. If you merely make something people want and don't spend too much, you're way ahead.
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Or picking a shit cofounder
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Loss of motivation would be a good number 3
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Making something nobody wants is part of the process to find what they do want, need to iterate quickly and keep motivation
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Id say if 1 person/company like Twitter wants something, no matter how specific, in this big wide world there'll be at least a few other people who want it too...
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Timing.
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That’s often (but not always) a 2nd order consequence of #1 and #2
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Problem - the symptom or disease. It has to exist. Product - the medicine. It needs to actually work. Position - the pill/syringe/saw. Go for the pill or the patch. Most people don't buy products, they buy positioning. The delivery medium for the medicine.
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3 is not separating product and positioning. Thinking that people will buy medicine when they are afraid of syringes (or not knowing how the medicine will get into the body). but yes, it's a distant 3rd to these 2
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