A pattern I've seen in many different fields: even though many people have worked hard in the field, only a small fraction of the space of possibilities has been explored, because they've all worked on similar things.
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Good example is Nuclear reactors. We got stuck in a uranium-based Pressurised Water Reactor minima for 5 decades. Molten Salt and Thorium almost entirely ignored.
The more costly projects are, the more you'll see this phenomenon.
