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patrickc's profile
Patrick Collison
Patrick Collison
Patrick Collison
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@patrickc

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Patrick CollisonVerified account

@patrickc

Fallibilist, optimist. Stripe CEO.

patrick@stripe.com
patrickcollison.com
Joined April 2007

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    1. Dan Wang‏ @danwwang Feb 15
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      Is it really the case that we’ve made no substantial progress on cancer? The current age-adjusted mortality rate is the same as in 1930, and the recent decline only tracks the fall in smoking.https://blogs.scientificamerican.com/cross-check/the-cancer-industry-hype-vs-reality/ …

      27 replies 94 retweets 418 likes
    2. Patrick Collison‏Verified account @patrickc Feb 15
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      Replying to @danwwang

      A very senior US cancer funding official recently told me that his view is that we’ve made very little progress in treatment since 1971. (And, to your point, that most mortality curves are confounded by non-treatment factors.)

      6 replies 9 retweets 104 likes
    3. Patrick Collison‏Verified account @patrickc Feb 15
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      Replying to @patrickc @danwwang

      I thought this was interesting since local incentives presumably push him to be *optimistic* about rate of progress.

      1 reply 0 retweets 12 likes
    4. Alexander Berger‏ @albrgr Feb 15
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      Replying to @patrickc @danwwang

      What about Gleevec et al? I'm sympathetic to the concerns over early diagnosis distorting the stats but there seem to have been some real innovations, moreso in cancer than other fields.

      1 reply 0 retweets 2 likes
      Patrick Collison‏Verified account @patrickc Feb 15
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      Replying to @albrgr @danwwang

      Yeah, he wasn’t denying that particular breakthroughs have happened. Just arguing that *overall* improvement (lifestyle- and detection-adjusted) has been slight.

      11:42 AM - 15 Feb 2020
      • 4 Likes
      • Libby Brittain eleanorina Alexander Berger
      3 replies 0 retweets 4 likes
        1. New conversation
        2. Jason Bade‏ @jasonwbade Feb 15
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          Replying to @patrickc @albrgr @danwwang

          Does he think we could be improve this with a different funding model? Or is this just the power law at work over a grand scale? Eg instead of betting on specific ideas or teams funding infrastructure (like let’s make micropipetting as cheap and automated as possible)

          1 reply 0 retweets 0 likes
        3. Patrick Collison‏Verified account @patrickc Feb 15
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          Replying to @jasonwbade @albrgr @danwwang

          In short, yes. NIH is screwed up (he agreed with all the usual critiques) but also more constrained by patient advocacy groups than might be obvious.

          1 reply 0 retweets 6 likes
        4. 9 more replies
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        2. José Luis Ricón Fernández de la Puente‏ @ArtirKel Feb 15
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          Replying to @patrickc @albrgr @danwwang

          José Luis Ricón Fernández de la Puente Retweeted Ashwin Varma

          I guess you have read SSC's take on this as linked herehttps://twitter.com/varma_ashwin97/status/1228778007558529025?s=19 …

          José Luis Ricón Fernández de la Puente added,

          Ashwin Varma @varma_ashwin97
          Replying to @danwwang @Noahpinion
          No. Go look at the progress in leukemia, HER-2+ breast cancer, and others. E.g. http://www.haematologica.org/content/101/6/657.figures-only … This article is just wrong on so many levels.
          1 reply 0 retweets 0 likes
        3. Ashwin Varma‏ @varma_ashwin97 Feb 15
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          Replying to @ArtirKel @patrickc and

          Also, I will die on the hill that population statistics are a *bad* way to measure medical innovation. By population-level metrics, the only two useful medicinal approaches were vaccines and antibiotics. But I'll then ask you to very kindly experience cardiac surgery in 1945.

          1 reply 0 retweets 3 likes
        4. 6 more replies
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        2. Stuart Buck‏ @stuartbuck1 Feb 15
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          Replying to @patrickc @albrgr @danwwang

          Maybe @VPrasadMDMPH can weigh in? He's generally a skeptic (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695531/ …).

          0 replies 0 retweets 0 likes
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