lmaooooooooooo same genotype leads to an order of magnitude different level of gene expression https://youtu.be/BConAUc7yCA?t=554 …pic.twitter.com/Aj9w3rBPW9
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digging into this right now!
According to the omnigenic model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536862/ … Much of the genome is interconnected regulatory networks. The more this is true, the more we will find many variants with small effect, that it's hard to pinpoint causal variants, and strong pleiotropic regulatory effects
When I was young I thought synthetic biology would be easy. Then I learned about the structure of proteins
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