A thing that keeps me up at night is that there is almost certainly, today, something which might not be shaped like penicillin but has a similar level of impact, and which is really sweating the next thousand dollars.https://twitter.com/jasoncrawford/status/1183833891209019392 …
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I think I'm working on something bigger than penicillin. It's improved methodology for rational discussion and thinking. However, it's hard to monetize, hard to get anyone to listen or use it, and hard to use funding to help the project.
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Most successful examples I can think of of popularizing "I simply think better than you" involve using single player mode to dominate valuable competitive environments until the entire world says "Oh eff me that parlour trick actually works." Sometimes this takes decades.
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Pls dm me when you see this
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I (felt) saw one and tried desperately, but they were all about the science, research and knowledge for the world and didn’t want to know anything about the money. 10 years and still trying
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But also remember, penicillin was a chance discovery, made because a glass broke NOT because of "directed" top down effort. But many bottom up experiments where you increase the chance of getting lucky The big national centres fail, the accidental tinkering works. Like in eng.
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A great modern philosopher once summarized this conundrum: https://en.wikipedia.org/wiki/There_are_known_knowns … Related: Hindsight bias.
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Competitive research grants would seem like the ideal solution: successful research gets funded, while unsuccessful research does not. However, I suspect that that approach has not and cannot work well.
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The problem is this is sentiment is expressed in the pharma model via monetizing statistical noise. As long as therapeutics with unknown MOA are so lucrative, we’ll have 10x Stemcentrx for every breakthrough like Car T where there is huge surplus in profit, impact, AND science
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