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Prikvačeni tweet

@TheLancet - Colorectal Cancer. Almost 2 years of effort. Finally in print!@UIowaCancer@MayoClinic@MayoCancerCare@mikewallacemd#CRCSM#ctDNA@IntMedatIowa#clinicaltrials#lancet#seminar#cancer#CancerAwareness Link to free full text/share
https://authors.elsevier.com/c/1Zvs2V-4X6~as pic.twitter.com/jjuUUPvuwI
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On
#WorldCancerDay
we really need to support more #research & engage in
biomarker driven #clinicaltrials. Advances for many of these cancers is coming for subsets. Cancers are heterogeneous
. One size fits all approach less likely to be successful. #CRCSM#PANCSM#HPBCSMpic.twitter.com/8a5KDLtagN
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#Cholangiocarcinoma is truly a
“TARGET-RICH”
disease.
For sure everyone
genetic testing. Often tissue is
. One area where 

#ctDNA#liquidbiopsies can fill that void.#BileDuctCancer#FebruaryCCAwareness#WorldCholangiocarcinomaDay#WorldCCADay#curecca#ctDNAInsightspic.twitter.com/xTnORgFlNV – mjesto: UIHC Holden Comprehensive Cancer Center
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I saw my
#cholangiocarcinoma pt described
in her YEAR

of Rx ē HER2
.
Picked up only because of #ctDNA#liquidbiopsies#ctDNAInsights#BileDuctCancer#FebruaryCCAwareness#WorldCholangiocarcinomaDay#WorldCCADay#curecca https://www.nature.com/articles/s41698-019-0091-4?utm_campaign=MultipleJournals_USG_CANCER&utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Cancer-Global …pic.twitter.com/tDuW8joBZi – mjesto: UIHC Holden Comprehensive Cancer Center
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Pashtoon Kasi MD, MS proslijedio/la je Tweet
#Clinicaltrials
REVERCE - intriguing PFS-2/OS differences
R
C 17.4m
C
R 11.6m
Value of #ctDNA#liquidbiopsies Different emerging mutations

RAS/EGFR/MET.
#CRCSM#ctDNAinsights “SEQUENCING”
varied outcomes. #OncoAlert@myESMO@Annals_Oncology https://www.annalsofoncology.org/article/S0923-7534(19)31033-6/fulltext …pic.twitter.com/sy5CBM0848
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Pashtoon Kasi MD, MS proslijedio/la je Tweet
intriguing in many ways to how we treat &
therapies
. These are tissue-RAS/RAF Wildtype #colorectalcancer patients that acquired RAS/EGFR

on #ctDNA#LiquidBiopsies. Cumulative t1/2
4months.
@myESMO#ctDNAInsights#OncoAlert@Annals_Oncology https://www.annalsofoncology.org/article/S0923-7534(19)31024-5/fulltext …pic.twitter.com/8tF7Huo3zA – mjesto: UIHC Holden Comprehensive Cancer Center
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#littlethings my own
space ē a window
#SaturdayThoughts#Iowapic.twitter.com/2HejkoB35c – mjesto: University of Iowa Hospitals & Clinics
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See what came in
today -
@RueschCenter & Drs.@marshalj23@benweinbergmd.#ctDNA#LiquidBiopsies#ctDNAInsights

pic.twitter.com/91S0HQcjrP
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Pashtoon Kasi MD, MS proslijedio/la je Tweet
MT
@pashtoonkasi [Sep 27, 2019] Number of actionable targets in this target-rich disease are increasing with encouraging results.#ESMO19#PrecisionMedicine#hpbcsmpic.twitter.com/F6yGK2mmcZ
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intriguing in many ways to how we treat &
therapies
. These are tissue-RAS/RAF Wildtype #colorectalcancer patients that acquired RAS/EGFR

on #ctDNA#LiquidBiopsies. Cumulative t1/2
4months.
@myESMO#ctDNAInsights#OncoAlert@Annals_Oncology https://www.annalsofoncology.org/article/S0923-7534(19)31024-5/fulltext …pic.twitter.com/8tF7Huo3zA – mjesto: UIHC Holden Comprehensive Cancer Center
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Anyone with experiences and/or thoughts on

#CHEK2 specifically from a metastatic cancer treatment standpoint? I found some pooled analysis of
platinum-based chemotherapy.https://esmoopen.bmj.com/content/5/1/e000578 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
#Clinicaltrials
REVERCE - intriguing PFS-2/OS differences
R
C 17.4m
C
R 11.6m
Value of #ctDNA#liquidbiopsies Different emerging mutations

RAS/EGFR/MET.
#CRCSM#ctDNAinsights “SEQUENCING”
varied outcomes. #OncoAlert@myESMO@Annals_Oncology https://www.annalsofoncology.org/article/S0923-7534(19)31033-6/fulltext …pic.twitter.com/sy5CBM0848
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Colleagues: see what you make of this
. Very informative answers from this study on questions at #GI20@Nature_NPJ@NatureNews#ctDNA#LiquidBiopsies@ShaalanBeg@marklewismd@agrothey@mdmanishshah@ILSONDavid@cancerassassin1@weldeiry@Aiims1742@HH_Oncodr@marshalj23pic.twitter.com/FJ7CZM6peF
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Is
#ctDNA just prognostic?
NO!
Can you change outcomes by CLEARANCE of #ctDNA?
YES!
Remember the terms
#ctDNA


Molecular Responder
#ctDNA

or 


Molecular Non-Responder
Provides a #clinicaltrials platform.#ctDNA#LiquidBiopsieshttps://www.nature.com/articles/s41467-020-14310-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
And especially if you had detectable DNA after your induction systemic chemo or ChemoXRT & surgery: Then you’re in trouble: ominous! Doesn’t get more black and white than this.
%
0%
#ctDNA#LiquidBiopsies#ctDNAinsights@Nature_NPJ@NatureNewspic.twitter.com/Jbs8V0a7pf
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This is from the CRITICS: ChemoRadiotherapy after Induction chemoTherapy In Cancer of the Stomach.
@NatureNews@Nature_NPJ 21.8
higher risk of disease
DFS: 18.7 m
median NR; p < 0.001; HR = 21.8;CI =3.9–123.1.
OS: 28.7
median NE; p < 0.001; HR = 21.8;CI =3.9–123.1pic.twitter.com/3LFQ4VmyCD
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#ctDNA


Molecular Responder
#ctDNA

or 


Molecular Non-Responder
Here it shows that it’s not just prognostic but predictive like we were proposing earlier.
Survival is not much different if you just detect; but if you CLEAR it after induction chemo,
survival.pic.twitter.com/ogUZzUw27W
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Bear with me as we dissect this landmark study answering some of the

raised at #GI20. Love the terms:#ctDNA


Molecular Responder
#ctDNA

or 


Molecular Non-Responder
@NatureNews@Nature_NPJ#ctDNA#LiquidBiopsies#OncoAlert https://www.nature.com/articles/s41467-020-14310-3 …pic.twitter.com/TbipHO1dMJ
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Pashtoon Kasi MD, MS proslijedio/la je Tweet
Excited about giving a talk on dysproteinemias at
#STIM2020 in Maui
!pic.twitter.com/ieCTet0kig
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Pashtoon Kasi MD, MS proslijedio/la je Tweet
With ctDNA ever more accurate that may detect resistant clones 1. (which the immune system does not recognize)
should we design #IO+ targeted Tx (TT) trials d/t ctDNA? Long-term dz control by only changing TT?@agrothey@FaltasLab@pashtoonkasi@gary_lyman#WeeklyMusings 109https://twitter.com/NicoleKuderer/status/1205179750206935042 …
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Why single drug approaches often fail
Ripple effects of a 
#RAS mutation We think of the pathway as: EGFR
RAS 
RAF
MEK
ERK
In reality
:

@NatureNews@Nature_NPJ@nresearchnews https://cancercommunity.nature.com/users/340607-walter-kolch/posts/58480-the-ripple-effects-of-a-ras-mutation?utm_source=newsletter_mailer&utm_medium=email&utm_campaign=newsletter …#OncoAlert#CRCSM#PANCSM#Cancerpic.twitter.com/pjzYwkZSHy – mjesto: UIHC Holden Comprehensive Cancer Center
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