Peter Park

@ParkLabGenomics

bioinformatics and genomics, applications to cancer and neuroscience

Boston, MA
compbio.med.harvard.edu
Vrijeme pridruživanja: travanj 2019.
6 fotografija ili videozapisa Fotografije i videozapisi

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  1. Prikvačeni tweet
    12. pro 2019.

    Multiple postdoc positions available in the lab! See A great deal of independence (if desired), a lot of exciting projects in cancer genomics/neurogenetics--single cell WGS, mutational signatures, CRUK Grand Challenge, antisense oligo therapeutics, etc

    11 proslijeđenih tweetova 14 korisnika označava da im se sviđa
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  2. 1. velj

    Connor Horton wrote his undergraduate senior thesis in my lab and just published part of it as this paper. Superb work, Connor! GiniQC: a measure for quantifying noise in single-cell Hi-C data

    2 proslijeđena tweeta 4 korisnika označavaju da im se sviđa
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  3. 1. velj

    Max (formerly with my lab, now with Po-Ru Loh) applies haplotype phasing to genotyping data from >10K autism cases to identify mosaic copy number variants! He also found two mosaic CNVs in brain WGS data

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  4. proslijedio/la je Tweet
    30. sij

    Tomorrow! (Friday) come down to for our latest Guppy Tank event, featuring innovations from George Church's lab and Peter Park's lab at . RSVP:

    2 proslijeđena tweeta 2 korisnika označavaju da im se sviđa
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  5. 30. sij

    My department just opened a search for a junior faculty member with interest in applying machine learning to the diagnosis and treatment of disease, broadly defined. More information:

    14 proslijeđenih tweetova 13 korisnika označava da im se sviđa
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  6. 6. sij

    Here is the flowchart of the algorithm. It is intuitively clear that algorithms that incorporate more features at the read-level should perform better (as some recent algorithms do); the hard part was coming up with enough true positives to train the classifier.

    1 proslijeđeni tweet 4 korisnika označavaju da im se sviđa
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  7. 6. sij

    Yanmei's paper is out today. MosaicForecast uses 30+ read-level features (+ML) to identify mosaic mutations in normal cells, where the variant allele fraction is << what you typically see in cancer cells. A key innovation is to use haplotype phasing to generate a training set.

    Accurate detection of mosaic variants in sequencing data without matched controls
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  8. 12. pro 2019.

    Jake presents his work from his recent Cell paper at this lung cancer meeting and wins the Grand Prize (10K)!

    Dr from analyzed whole-genome sequencing datasets of EGFRm lung adenocarcinomas to elucidate possible mechanisms of mutagenesis
    8 korisnika označava da im se sviđa
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  9. proslijedio/la je Tweet
    6. pro 2019.

    We're inspired by all the great talks at the annual meeting this year & excited for phase 2! Reach out to us at support@4dnucleome.org to submit your recent data!

    4 proslijeđena tweeta 7 korisnika označava da im se sviđa
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  10. 9. lis 2019.

    2/2 This article tells the story of discovering a transposon insertion (from whole-genome sequencing) that caused a splicing defect in CLN7, developing an antisense oligonucleotide drug, and the therapy resulting in reduction in seizures--all in <1 yr.

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  11. 9. lis 2019.

    1/2 Just out: "Timely Development of a Mutation-Specific Drug", with an accompanying editorial, on the front page of NEJM. Congrats to the lead author Jinkuk Kim (a postdoc in the lab), who worked with our collaborator on this amazing story.

    15 proslijeđenih tweetova 34 korisnika označavaju da im se sviđa
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  12. 8. lis 2019.

    It was wonderful to discuss some of the challenges we face in data analysis with the many thoughtful editors at the Cell Press office in Cambridge!

    Very grateful to for coming in today to give our editors a refresher on appropriate use of statistics to help us help our authors more effectively.
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  13. 12. ruj 2019.

    It's wonderful to welcome 12 accomplished students to our Bioinformatics & Integrative PhD program this fall!

    3 proslijeđena tweeta 38 korisnika označava da im se sviđa
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  14. 11. ruj 2019.

    A lab outing to the Boston Harbor Islands last week!

    1 proslijeđeni tweet 12 korisnika označava da im se sviđa
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  15. 29. kol 2019.

    Joe's SCAN-SNV (Single Cell ANalysis of SNVs) paper is out. To deal with allelic imbalance, Joe determines whether a candidate SNV is a FP based on the allelic imbalance at nearby SNPs. Interestingly, he finds that a "single cell" in a Nat Methods paper is actually a doublet!

    Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
    4 proslijeđena tweeta 13 korisnika označava da im se sviđa
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  16. 28. kol 2019.

    We're excited to see Isidro, a Park lab alum, start his own group at EMBL-EBI. He is a terrific computational scientist, a generous colleague, and a wonderful collaborator--we'll miss you in Boston, Isidro!

    We are very excited to welcome as a new Group Leader studying genomics. Find out more about what his group does in this short Q&A. Spoiler alert: he is currently recruiting!
    1 proslijeđeni tweet 20 korisnika označava da im se sviđa
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  17. 15. kol 2019.

    Analyzing allelic fractions of SNVs as molecular clocks while accounting for CNVs and SVs, Lixing has painstakingly constructed evolutionary history of tumors from bulk WGS data.

    Yang, and co analyze the timing of mutations in 63 colorectral tumors, identifying key events. Different mechanisms act on different regions. Chromothripsis can occur many times in the same tumor.
    6 proslijeđenih tweetova 23 korisnika označavaju da im se sviđa
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  18. 14. srp 2019.

    Boston in the summer

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  19. proslijedio/la je Tweet
    19. lip 2019.

    Congratulations to my colleague on being installed as the inaugural Gilbert S Omenn MD ‘65, PhD Associate Professor of Biomedical Informatics . Well deserved and well done, Peter! – mjesto: Harvard Medical School Quadrangle

    Korisnici , , i
    3 proslijeđena tweeta 29 korisnika označava da im se sviđa
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  20. 20. lip 2019.

    Congrats to Peter K ()! It was a privilege to have him as a postdoc in my lab, and I relished the opportunities to speak about his science and his many other talents at the ceremony!

    So pleased to hear present the new Gil Omenn chair to Peter Kharchenko is a huge vote of confidence in Peter and in our Department
    1 reply 2 proslijeđena tweeta 34 korisnika označavaju da im se sviđa
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