Sergio Kaiser, M.D., PhD, FACC, FESC

@pabeda1

Cardiologist, professor of Internal Medicine, Rio de Janeiro State University. Main interests: Hypertension, lipids, atherosclerosis, art, politics, music.

Rio de Janeiro, Brasil
Vrijeme pridruživanja: listopad 2012.

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  2. Leadless pacemaker technology reaches a new benchmark! Medtronic gets OK to sell next generation of pacemakers that fit inside the heart

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  3. proslijedio/la je Tweet
    2. velj
    Odgovor korisnicima i sljedećem broju korisnika:

    The effect of icosapent ethyl on various inflammatory markers is interesting, including dose-related effects. Really does support pleiotropic effects of the 4 grams a day that was found to be so effective in REDUCE-IT.

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  4. Thrilled to know that the new egyptian museum will open by the end of 2020. No collection anywhere in the world gets close to the treasures exposed there. Wonder if the statue of Ramses II at the entrance is the same from Memphis.

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  5. A recent metanalysis including Vital , Ascend and Reduce-it, suggests benefits on CVD endpoints even when excluding Reduce-it (10.1161/JAHA.119.013543). I look forward to knowing the full data from Strenght, but so far, Vascepa is the only one (For 2nd time, remember JELIS!).

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  6. Fernando, there are indeed differences between EPA and DHA for LDLc and apoB lowering (EPA) and raising (DHA) a few differences in design, like HDL, for instance and uncertainty about anti-inflammatory actions of DHA compared to a robust effect of Vascepa on CRP. But...(follows)

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  9. #4 Due to relatively small sample size there might not be sufficient cases to warrant a definite conclusion. So, IMHO, further studies could include pursuing athero by US scanning in 1 or 2 additional territories. Opinions, if desirable, would be welcome!

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  10. #3 10.1016/j.atherosclerosis.2019.09.014 and editorial: 10.1016/ j.atherosclerosis.2019.11.019. What if some had CAC=0 but atherosclerosis in carotid and/or femoroiliac territories? Here, no data were available, but even so, it'd have made no difference, unless...

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  11. #2: Predictors of CAC progression: classic RF's except for...low HDL. As suggested by in his editorial: CAC zero passed another test. Larger samples needed, some limitations, but main message: one size may not fit all, as guidelines recommend. DOI's follow next:

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  12. #1 Fascinating data: Should we treat all pts w/out CVD and LDL>=190 mg/dl w/high potency statins+probably ezetimibe+possibly PSCK9i? 90/246 w/LDLc>=190 had CAC=0. Mean age 63, median FU 13 yrs. Very low HRs for CHD, CVD, all cause death! High CAC predictors: Classic RF's...

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    29. sij

    New triglyceride-lowering therapy alert! A dual apoC-II mimetic–apoC-III antagonist peptide promotes lipolysis and lowers plasma triglycerides

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  15. #3 I suspect that John McMurray and cols, must already be greedily exploring the same potential interaction in the DM and non-DM cohort of DAPA-HF !!

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  16. #2 Several different sensitivity analyses provide support to the findings. This study will surely foster mechanistic trials aimed at unveiling potential interactions between SGLT2i and AFib/flutter.

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  17. #1 A few years ago, no one would ever imagine that SGLT2i were such powerful drugs to prevent/treat HF. Initial analyses were exploratory, just like this one: Upon designing DECLARE, researchers were not thinking of A-Fib. In compensation...

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    29. sij

    How important is ELSA-Brasil. The Need for Prospective Studies in Varied Populations To Identify Disease Risk Factors

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  19. proslijedio/la je Tweet
    29. sij

    No association of Egg Intake (≥7 egg/wk compared with <1 egg/wk intake) with blood lipids, CVD, and mortality in 177,000 People in 50 Countries

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    28. sij

    Association Between Isolated Diastolic Hypertension Defined by the 2017 ACC/AHA Blood Pressure Guideline and Incident CVD Important work by isolated is not the same as isolated HTN!!!

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