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Prikvačeni tweet
Arthur Rock on what it takes to start a new company (1984): http://amzn.to/1ze3uU9
#entrepreneurpic.twitter.com/9vmtIMSsHM
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"When dealing with complex systems governed by feedback loops, circular causality, and large-scale setpoints, the control structures (causes) are not obvious and hard to determine; they are often distant, both spatially and temporally, from the event in question."
#BiologyHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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discovered a very efficient way to control system-level outcomes: rewriting large-scale homeostatic setpoints and letting the system regulate to them, instead of micromanaging all of the myriad low-level details to achieve the desired outcome in the face of novel circumstances."
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"Recent advances in information theory confirm that the most salient causes in a system are not always found at the lowest level of organization (in this field, often thought to be subcellular biochemistry). "The widespread prevalence of modularity reveals that evolutionpic.twitter.com/NVsPuHoo2v
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#CTCF Translates#IL2 &#αKG-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs https://www.cell.com/immunity/fulltext/S1074-7613(17)30322-9 … "It might provide an explanation for how metabolic changes can both positively or negatively influence opposing gene programs in the same cell type."Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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But different teas have different unique bioactive compounds beneficial for health via different mechanisms, for example
#EGCG from green tea,#Theasinesins from oolong tea &#Theabrownin from Pu-erh tea:https://www.nature.com/articles/s41467-019-12896-x …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Time to suggest something better than CRM's, namely YFM's (
#YouthFactorMimetics): Black tea derived Theaflavin 3-gallate (#TF2A) mimics hypothalamic youth factor#Hnscr and protects against aging-associated physiological decline. https://www.sciencedirect.com/science/article/abs/pii/S1550413120300024 …#Antiagingpic.twitter.com/u86GJz2Mcf
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“At some point the word ‘strategy’ becomes a euphemism for procrastination." —Peter Thielpic.twitter.com/MkEaPG9WeA
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"These prospective, community-based data suggest that
#vitaminD deficiency is associated with increased CVD risk, above & beyond established CV risk factors." https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.107.706127 … "Vitamin D supplementation reduced the risk of cancer death by 16%. "https://www.bmj.com/content/366/bmj.l4673 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Interesting paper/thread about
#oxytocin, evolution & more: https://twitter.com/dsquintana/status/1156942118985916417 …pic.twitter.com/wBfthpr7qO
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Interesting concept: Preclinical Reversal of
#Atherosclerosis by FDA-Approved Compound (#Cyclodextrin) that Transforms Cholesterol into an Anti-Inflammatory “Prodrug”. https://www.liebertpub.com/doi/full/10.1089/rej.2016.1849 …https://stm.sciencemag.org/content/8/333/333ra50 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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It will be a combination & why wouldn't it be natural molecules? After all, in a period the body produces what it needs to keep us young. https://www.aging-us.com/article/102148/text … "We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging."pic.twitter.com/SdKwzu9mZu
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1LIFEMAX proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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1LIFEMAX proslijedio/la je Tweet
"Real
#strategy—in companies and in our lives—is created through hundreds of everyday decisions about where we spend our resources. As you’re living your life from day to day, how do you make sure you’re heading in the right direction? Watch where your resources flow." RIPpic.twitter.com/Cmchq5qCxe
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"I’ve changed some ideas as I’ve learned more. Uber helped me realize that it isn’t that being at the bottom of the market is the causal mechanism but that its correlated with a business model that is unattractive to its competitor. https://www.forbes.com/sites/forbestreptalks/2016/10/03/clayton-christensen-on-what-he-got-wrong-about-disruptive-innovation/#9cb5419391bb …https://www.youtube.com/watch?v=IkBp1ntD3Zc …
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"It's easier to hold your principles 100 percent of the time than it is to hold them 98 percent of the time." -- Clayton Christensen, giant of enterprise, RIP
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Nature seems to have limited affinity for people over ~30. All the fasting & cold exposure in the world won’t make a material difference. Only «Youthful signalomic recalibration» via defined pharmacology (hopefully as natural as possible) can help ushttps://aging-us.com/article/102148/text …
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“We stopped a bunch of things on the theory of ‘do less better.’ Next, I believe if you’re going to change you’ve got to have some evidence of success inside your own company." -Scott Cook, Intuit Watch the full video: http://bit.ly/2Wrsh8Q pic.twitter.com/VmJtG06b36
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Another amazing talk. The future of cancer research unfolding! James P. Allison – Nobel Lecturehttps://www.nobelprize.org/prizes/medicine/2018/allison/lecture/ …
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Likely
#Systemicinflammation as always: Abrogation of#TLR4 mitigates obesity-induced oxidative stress, proinflammation, and insulin resistance https://www.liebertpub.com/doi/abs/10.1089/ars.2019.7737 …#NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesityhttps://www.frontiersin.org/articles/10.3389/fimmu.2019.01621/full …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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More confirmation from
@JCIB_Lab_Salk: "the study of#TGFβ1 levels in the knee joint of human patients suggests that active TGFβ levels are very low or absent in healthy articular joints, while drastically elevate in joint diseases such as#Osteoarthritis"https://link.springer.com/article/10.1007%2Fs13238-019-00685-7 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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