THREADTHREADTHREADTHREAD 

#pain (h/t @o_guest)https://twitter.com/pookleblinky/status/838493273475923969 …
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(sorry you're angered though)
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I'm probably too sensitive. But ppl make large claims bar pain that are unfounded. Can lead to poor clinical decisions
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certainly
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also just to clarify, no such thing as "too sensitive". I appreciate your sensitivity giving rise to this convo.
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pain doesn't overwhelm systems, or shut any down. Pain is inherently salient, but if competing with equally salient 1/
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stimuli, it actually comes down to motivation, much like any other stimulus.
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in fact, pain is indistinguishable from other stimuli in a univariate fMRI study (see Mouraux et al, Neuroimage 2010)
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and different people cope differently. In healthy subjects, cog tasks are performed either faster or slower in pain 1/2
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depending on the person, context, etc. See:
@daspainbrain &@kren27's work -
thanks for the pointers!

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happy to share. I do think that pain serves as an alarm, but so can any other stim modality
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in fact patients w/ Nav1.8 mutations who are partially cong analgesic (see:
@head_like_egg) *must* develop such defences
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