there are unfortunately a bunch... it's called antagonistic pleiotropy and it's a large part of the reason that the average XY lifespan is shorter than the average XX lifespan :/
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Replying to @bi_gendian @stellahymmne
Hmm, not sure that's true? I'm not an expert. But X inactivation means it doesn't matter if one has XY or XX only one X is active. https://en.m.wikipedia.org/wiki/X-inactivation …
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Replying to @o_guest @stellahymmne
I know about X inactivation, but unfortunately having two copies of a gene means you're more likely to have at least one functioning copy. this is what allows XX people to act as carriers for otherwise lethal mutations
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Replying to @o_guest @stellahymmne
it just bothers me because the Y chromosome is clearly doing good stuff but people often equate it with masculinity
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Replying to @bi_gendian @stellahymmne
Reductionists don't understand. Evergreen point.
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Replying to @o_guest @stellahymmne
it's a problem for health bc XY individuals will have declining health as their body starts to reject the Y chromosome upon getting older. cw gendering in thishttps://www.sciencedaily.com/releases/2014/04/140428121205.htm …
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Replying to @bi_gendian @stellahymmne
Maybe we in future we can crisper everybody with XX, if there is a health component. (Being a bit facetious!) How do these things play out when they interact with the cultural correlations of karyotypes? Like women (cis and trans) live longer with respect to genetic diseases?
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Replying to @o_guest @stellahymmne
that I don't know. my hunch is that in terms of longevity, assuming you live past 50, the expected lifespan ranking is 1. trans women 2. cis women 3. cis men 4. trans men
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here's why I think this: 1. orchiectomy associated with much longer lifespan (see research on eunuchs) 2. post-menopausal estrogens associated with longer lifespan 3. XY genotype associated with shorter lifespan 4. supplemental testosterone associated with shorter lifespan
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Interesting. I assume not controlling for other factors trans people live the shortest though (social issues, medical discrimination, etc), right?
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Replying to @o_guest @stellahymmne
yeah unfortunately the average trans life expectancy is super low due to the number of us who die young
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