The return of fMRI's dead salmon.
Well not quite, but still: haemoglobin concentration is a confounding factor in connectome measures. Would it affect activation studies as well? @practiCalfMRI @fMRI_guyhttps://twitter.com/biorxivpreprint/status/1192986640580587522 …
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Which could still be a problem if claiming differences across sex, age or pathology groups . Would want to use [Hb] as a confound variable.
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You think local blood volume varies any less between areas and subjects? I bet that is a bigger confound than [Hb], especially in disease, atrophy, development. We should also measure BV across the brain and QSM for baseline oxygenation then. Complicated!
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Hb won't be the same everywhere due to variations in vascular density and sensitivity to Hb varies with vessel dia and orientation. I realize you know this but wanted to weigh in with the thought that large vessel Hb is only one of the variables we would like to control for
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Yeah, I added that in another tweet related to blood volume. There are a myriad intrinsic biological factors that can modulate the signal, but in general, task based stuff is pretty consistent and Fc ain't that bad either. Not sure we can do much better without hrs of scan time.
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