This project began much differently - tinkering around with this fun CA of evolution over simulated spatial antibiotic landscapes inspired by @baym @conTaminatedsci @RoyKishony. 2/npic.twitter.com/h07PTTTZyv
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While making sense of the rate of substitution and genetic diversity in each simulated CA grid cell, we sat out to answer some of our questions - I began staring at a stochastic Fisher wave with beneficial mutants 3/npic.twitter.com/Te5i49vw1d
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Delving into the amazing literature on evolutionary dynamics on range expansion as well as classical population genetics texts, we set out to characterize the clonal interference between multiple beneficial mutants along a migrating frontpic.twitter.com/VQRWmxvVL6
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We did so using what we termed a 'clonal interference index', derived from comparison of avg. fixation and establishment times of a beneficial mutant arising at each position. 4/npic.twitter.com/BciKzRhg9C
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Drawing analogy to classic evo. regimes we found that evolution is mutation-limited (SSWM) at the far extent of the wave tip, and subject to clonal interference away from the tip - maximally so at a position between the origin and tip of the front. 5/npic.twitter.com/qzFDbNIn0x
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We welcome feedback from others who have been thinking about this for much longer than us. hope to improve and refine this as we continue exploring 6/6!
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