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After >2 years of effort by our team in 7 labs, we present to you: 3 million choices from 101 mice in a standardized decision-making task.
"A standardized and reproducible method to measure decision-making in mice" https://doi.org/10.1101/2020.01.17.909838 …
Story time! 
1/10pic.twitter.com/WBdJh7A0eb
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Why is it that it only takes one snow dump in Washington DC for climate change deniers to take comfort in their position, but that a 70 degree day in the middle of January does not equally lead them to question it?pic.twitter.com/Sr0QlV27mg
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Save the Date! The 2021 GRC on Catecholamines is scheduled for August 15-20, 2021 at Rey Don Jaime Grand Hotel, Castelldefels, Spain. The associated GRS is scheduled for August 14-15 at the same location.
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Precise timing in neural circuits can be generated in spite of (due to?) substantial axonal transmission delays! Find it paradoxical? Read this fantastic preprint - Egger et al - from Mike Long’s lab
@mlong11215 at@nyuschoolofmedhttps://twitter.com/biorxiv_neursci/status/1202646553313325057 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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VTA GABA neurons are so hot right now! So we wrote a review all about them, you can check it out here:https://www.frontiersin.org/articles/10.3389/fncir.2019.00078/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Neural_Circuits&id=479774 …
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Big thank you to
@VMurthyLab /@UtopianCynic for providing valuable comments on our preprint recently posted at bioRxiv. This will definitely improve the next version of the manuscript. It is great to have http://bioRxiv.org !!!https://www.biorxiv.org/content/10.1101/841916v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Big Congrats to postdoc Marta Maltese with help from Jeff March and Zander Bashaw
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Our work also provides novel insights into the pathophysiology of Parkinson’s disease and a possible explanation for why long-term levodopa treatment eventually induces uncontrolled involuntary movements
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Our results indicate that DA regulates striatal output by dynamically reconfiguring its sparse ensemble code and suggest that DA modulates how many target neurons are eligible for synaptic plasticity
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In addition, we show that dSPN and iSPN ensembles do not adapt similarly to chronic loss of dopamine in a model of Parkinson’s disease and respond differently to subsequent dopamine replacement therapy
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Surprisingly, dopamine does not strongly or differentially modulate the frequency of calcium transients in either pathway
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By contrast, dSPNs follow an “inverted-U” shaped response, where too little or too much dopamine negatively impacts ensemble size
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Specifically, we show that iSPN ensembles are inversely related to extracellular dopamine levels, in general agreement with current notions of dopamine action
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Here, we use two-photon microscopy to monitor intracellular Ca2+ signals in dSPNs and iSPNs simultaneously and find that the overall number of dSPNs and iSPNs encoding motor actions is not fixed, but is rather dynamically modulated by dopamine
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To date, this has largely been understood in the context of mean firing rate, with dopamine increasing the discharge of dSPNs while depressing that of iSPNs
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Dopamine is at the heart of basal ganglia circuits controlling self-paced motor actions, where it is believed to act by differentially modulating direct- and indirect-pathway striatal projection neurons (dSPNs and iSPNs)
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Delighted to share my lab’s first manuscript and preprint, in which we look at how acute and chronic dopamine manipulations affect striatal activity.https://biorxiv.org/cgi/content/short/865006v1 …
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Very excited to share my first preprint and the first preprint from the
@KhaliqLab ! We use dendrite-specific optogenetics to functionally compare genetically-defined sources of inhibition onto SNc dopamine neurons.https://www.biorxiv.org/content/10.1101/856617v1 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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It is a curious fact that the neurotransmitter which signals reward prediction error, teaching us about stimulus value, also invigorates actions that are associated with that stimulus. This short article considers the link between the two control systems.https://twitter.com/huwbris/status/1198860565491245056 …
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Don’t miss out on your chance to make your science center stage at
#SfN20. Submit a symposium or minisymposium proposal by January 7 at https://bit.ly/2QEb0Fb .pic.twitter.com/2AMp3HfzTQ
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