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nataliexdean's profile
Natalie E. Dean, PhD
Natalie E. Dean, PhD
Natalie E. Dean, PhD
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@nataliexdean

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Natalie E. Dean, PhDVerified account

@nataliexdean

Assistant Prof of Biostatistics at @EmoryRollins, @EmoryBIOS, @EmoryEPI. Emerging infectious diseases & vaccine study design. Previously @UF @HarvardBiostats.

Emory University
nataliexdean.com
Joined June 2018

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    Natalie E. Dean, PhD‏Verified account @nataliexdean 24 Nov 2020

    Astrazeneca/Oxford get a poor grade for transparency and rigor when it comes to the vaccine trial results they have reported. This is not like Pfizer or Moderna where we had the protocols in advance and a pre-specified primary analysis was reported. 1/5

    1:53 PM - 24 Nov 2020
    • 1,031 Retweets
    • 3,909 Likes
    • Carol Jones i_Asghar أصغر حسين Ana ن​ 🎄 Martin Marek Andrés Gallardo Magenta punbroker Ann-Catherine Mörner Matteo Zamperetti ⚛️ zampemo.xpr
    93 replies 1,031 retweets 3,909 likes
      1. New conversation
      2. Natalie E. Dean, PhD‏Verified account @nataliexdean 24 Nov 2020

        AZN is evaluating their vaccine in multiple trials across the world, yet these are not embedded under a unified protocol. In fact, the trials seem to be quite different by country, in terms of populations, subgroups, etc. Based on the publicly available details I've seen. 2/5

        5 replies 65 retweets 525 likes
        Show this thread
      3. Natalie E. Dean, PhD‏Verified account @nataliexdean 24 Nov 2020

        With the exception of the US-based trial, I am not aware of details on how these trials are being monitored. Is there a centralized DSMB? Are they combining the accrued data? They seem to have combined events across Brazil and UK. Why not the other countries? 3/5

        3 replies 44 retweets 437 likes
        Show this thread
      4. Natalie E. Dean, PhD‏Verified account @nataliexdean 24 Nov 2020

        And reporting out a secondary analysis that was not pre-specified (since it seems to be based on a dosing error) is not desirable. If they seek to get the half-dose approved, they should wait until they have a compelling result. Otherwise, we can land in "evidence limbo." 4/5

        9 replies 53 retweets 517 likes
        Show this thread
      5. Natalie E. Dean, PhD‏Verified account @nataliexdean 24 Nov 2020

        All of this to say, I really don't know what to make of the results, but as @Dereklowe and others have said, I'm glad this is not the first vaccine to read out, because it is awfully confusing for experts and non-experts alike. 5/5

        20 replies 54 retweets 721 likes
        Show this thread
      6. End of conversation
      1. New conversation
      2. Nirav B‏ @niravb 24 Nov 2020
        Replying to @nataliexdean

        Are they evaluating the same vaccine with same dosage in other countries or is it different too?

        1 reply 0 retweets 3 likes
      3. markinthedark‏ @pre176 24 Nov 2020
        Replying to @niravb @nataliexdean

        On their press release it looked like the half dose was only U.K.

        1 reply 0 retweets 3 likes
      4. Show replies
      1. New conversation
      2. Ketan Kurtadikar‏ @KurtadikarKetan 24 Nov 2020
        Replying to @nataliexdean @deeptabhattacha

        @hildabast is an expert on reporting on this particular trial.

        1 reply 1 retweet 15 likes
      3. Hilda Bastian, PhD‏ @hildabast 24 Nov 2020
        Replying to @KurtadikarKetan @nataliexdean @deeptabhattacha

        My article is in the final editing round, so coming soon I hope.

        3 replies 2 retweets 63 likes
      4. Show replies
      1. New conversation
      2. gavinashun‏ @gavinashun 24 Nov 2020
        Replying to @nataliexdean

        As someone who has worked for 15 years in biopharma ... this whole thing seems just ridiculously amateurish. Just mind boggling.

        3 replies 5 retweets 84 likes
      3. Anand C. Patel‏ @anandcpatel 24 Nov 2020
        Replying to @gavinashun @nataliexdean

        This. 💯

        0 replies 0 retweets 6 likes
      4. End of conversation

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