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nanogenomic's profile
Andre Watson 🧬
Andre Watson 🧬
Andre Watson  🧬
@nanogenomic

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Andre Watson  🧬

@nanogenomic

Founder & CEO @Ligandal 🧬💊🦠 Biomedical engineer + scientist developing #nanomedicine for COVID and #genetherapy. Forbes #30Under30 in Healthcare 2021. 🎼🎹

nanobio.eth
ligandal.com
Joined March 2016

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    Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

    I bought a one-way ticket to Silicon Valley when I was 21. I had just finished my bachelor’s in Biomedical Engineering at Rensselaer Polytechnic Institute where I worked with TALENs and created a gene editing, nanoparticle-based delivery system for editing mice.

    11:17 PM - 5 Jun 2020
    • 15 Retweets
    • 83 Likes
    • Ethan Fenton🎒 Juan Bujanda George Metaxas Erik Saether José Luis 🏛️ᴍ.ᴄ.ʀ.ᴄ. 🇪🇸🇮🇨 Igor Elalterego01 Elliot Beaudoin Nancy Saucedo-Sweet
    4 replies 15 retweets 83 likes
      1. New conversation
      2. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        The first years were tough. People would always ask, “what makes you think you can...” style questions. VCs would play games. It was like Silicon Valley, the TV show.

        2 replies 2 retweets 13 likes
        Show this thread
      3. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        In 2017 we raised a seed round. With that cash we built a state-of-the-art, highly automated lab capable of everything from peptide synthesis to fluid handling automation and automated cell imaging, with integrated data outputs.

        1 reply 1 retweet 9 likes
        Show this thread
      4. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        We showed we could delivery CRISPR using peptides to edit T cells, achieving industry-best non-viral delivery system efficiency.

        1 reply 1 retweet 11 likes
        Show this thread
      5. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        I won’t get into the half a dozen or more hostile takeover attempts we survived during the course of our Seed and Series A raises, some after signed term sheets and completed diligence.

        1 reply 2 retweets 9 likes
        Show this thread
      6. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        Then, COVID19 hit. We had built a novel approach for making peptides that are modeled off larger proteins. We had previously used this technique to create the world’s first universal cell-specific targeting technology using peptides to package up mRNA, DNA, CRISPR, and beyond.

        1 reply 1 retweet 17 likes
        Show this thread
      7. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        COVID: by modeling the outside of the virus, it would be possible to make synthetic peptides that act like decoys, preventing the virus from entering cells. Additionally, the decoys would be able to expose the virus and present their own epitopes for forming antibodies.

        1 reply 2 retweets 15 likes
        Show this thread
      8. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        So, 2020 has been focused on COVID. Peptide nano-scaffolds. No gene therapy or editing necessary. Comparatively, a more simple project.

        2 replies 1 retweet 14 likes
        Show this thread
      9. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        Founders: hang in there. Entrepreneurship, and especially building hard things with worldwide impact, takes its tolls. You must take care of yourself. The more valuable what you’re building is, the more people will try to take things from you, the more people will denigrate you.

        1 reply 4 retweets 25 likes
        Show this thread
      10. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        Persist. At times, your credit and debit cards may not work for months at a time. You may wonder how you’ll make it another week, let alone another month or year. Great things are born out of surviving these moments and not giving up or selling out. You are not alone.

        1 reply 2 retweets 23 likes
        Show this thread
      11. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        Keep building value. Believe in yourself. If you don’t believe in the project, find something you believe in, as this will be the only thing that keeps you going when things are tough.

        2 replies 2 retweets 16 likes
        Show this thread
      12. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        The story is still manifesting. There will be more struggles, more successes, more moments of elation, and more moments of staring into the abyss. That is the nature of things. We must let these experiences flow throw us and become better, constantly.

        1 reply 1 retweet 15 likes
        Show this thread
      13. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        There is only so much that can be said on Twitter, or in a book. Many stories never get told. All in all, it’s a beautiful experience, and invaluable. It is not easy. People see the bright shining stars, but they don’t see the darkness of the soul that comes with the territory.

        1 reply 0 retweets 14 likes
        Show this thread
      14. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        At some point, you separate yourself from the equation. You learn to take care of yourself. To feed yourself. To sleep well. Those that don’t, burn out after a couple of years. You must be able to withstand many years of not having a sure paycheck, and fighting month to month.

        1 reply 1 retweet 13 likes
        Show this thread
      15. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You learn that the vision is bigger than yourself. So you must care for yourself. The anxiety of sending the email, posting the post, saying the thing — it all fades away. You start to see the cracks in the system. You start to see the opportunists and the sycophants.

        1 reply 2 retweets 14 likes
        Show this thread
      16. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You persist. What you are building drowns out all the noise.

        1 reply 1 retweet 9 likes
        Show this thread
      17. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You end up focusing on the future. On the world that must be built. Flowing attention towards the final state. You ignore friends, family and colleagues encouraging you to compromise. You withdraw for months at a time because no one understands. That is entrepreneurship.pic.twitter.com/3CuFkws6Ct

        1 reply 4 retweets 12 likes
        Show this thread
      18. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You clear your mind and your soul and continue on the path that no one has walked.

        1 reply 2 retweets 9 likes
        Show this thread
      19. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You withstand psychological abuse, torment, gaslighting, and months of being led along. You learn that there really are awful people in this world. You find ways to maintain purity of your soul and heart and keep going anyway. Making more mistakes, but not the same exact ones.

        1 reply 2 retweets 11 likes
        Show this thread
      20. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        You improve. Continuously.

        1 reply 1 retweet 8 likes
        Show this thread
      21. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        We have a big, dark, beautiful, at times luminous world that needs to be changed. The neutral and passive majorities outweigh the good and the bad. But passivity in the face of evil expands the sphere of influence. Fighting these battles isn’t easy.

        1 reply 2 retweets 8 likes
        Show this thread
      22. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        They will try to take everything from you. At times, they will try to destroy your reputation, while being the same ones to smile at your face and tell you they always believed in you when you are successful. The wolves in sheep’s clothing and vultures run rampant.

        1 reply 2 retweets 10 likes
        Show this thread
      23. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        We must not compromise to these actors. The good, fearful & neutral players must take a stand and support foundational innovation and entrepreneurs building core improvements to the world and its bleeding heart. We don’t have much time to reverse all of the damage we’ve caused

        1 reply 3 retweets 11 likes
        Show this thread
      24. Andre Watson  🧬‏ @nanogenomic 5 Jun 2020

        and this world is more about just us. It’s about the generations that come after us. It’s about maintaining the health of the planet and fighting against corrupt systems that only benefit the few, to the detriment of many. We must become more efficient, smarter, and less greedy.

        4 replies 1 retweet 13 likes
        Show this thread
      25. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        Founders are: 2X more likely to suffer from depression 6X more likely to suffer from ADHD 3X more likely to suffer from substance abuse 10X more likely to suffer from bi-polar disorder 2X more likely to have psychiatric hospitalization 2X more likely to have suicidal thoughts

        2 replies 2 retweets 19 likes
        Show this thread
      26. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        Why? Is it innate that founders experience these things? To some extent, you have to live at the boundaries to go out and start something — yes. On the other hand, few people realize the actual conditions of starting companies.https://www.thewealthadvisor.com/article/silicon-valley-has-mental-health-crisis-too …

        1 reply 2 retweets 11 likes
        Show this thread
      27. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        Founders are told to be tough, to present an image, not to show weakness, to show prowess, to show that they know how to be cold-hearted, ruthless businesspeople. You must stand up for yourself, yes. And yet, this gauntlet shoots those in the foot trying to make a difference.

        2 replies 1 retweet 6 likes
        Show this thread
      28. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        A lot of patterns of cycles of abuse seem to propagate into the community, especially with VC - founder relations. The relationship of venture capitalists with entrepreneurs is inherently sociopathic. You learn that there is an entire category of people who are not your friends.

        1 reply 1 retweet 8 likes
        Show this thread
      29. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        Or so you are taught. The good apples get mixed with the bad. The VCs fight for their LP returns, for the hot deal, for derisking their investment, for pushing for a sale. And yet, their very philosophy holds back the process of innovation itself. It eats companies alive.

        1 reply 2 retweets 7 likes
        Show this thread
      30. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        The few who do succeed either sell out, or build something that has extreme impact, but they too usually sell out. When you see how investors behave when you have potentially life-saving medicine, and that they look at revenue and partnering models as if you’re building an app...

        1 reply 2 retweets 8 likes
        Show this thread
      31. Andre Watson  🧬‏ @nanogenomic 6 Jun 2020

        ...you begin to ask questions. Why does this person who doesn’t know what an immune cell is think that they understand your business better than you do? Why does this person keep saying that you’re like a son to them, but insist on taking over your board?

        1 reply 2 retweets 11 likes
        Show this thread
      32. Show replies

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