Skip to content
  • Home Home Home, current page.
  • Moments Moments Moments, current page.

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
nanogenomic's profile
Andre Watson 🧬
Andre Watson 🧬
Andre Watson  🧬
@nanogenomic

Tweets

Andre Watson  🧬

@nanogenomic

Founder & CEO @Ligandal 🧬💊🦠 Biomedical engineer + scientist developing #nanomedicine for COVID and #genetherapy. Forbes #30Under30 in Healthcare 2021. 🎼🎹

nanobio.eth
ligandal.com
Joined March 2016

Tweets

  • © 2022 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    Andre Watson  🧬‏ @nanogenomic 26 May 2020

    Here is the virus in "closed" (teal) and "open" (green) form. In "open" form, it binds to ACE2. ACE2 also blocks the ideal neutralizing antibody sites, and binds with extremely high, picomolar affinity (similar binding strength to many strongly binding antibodies).pic.twitter.com/dzVAV31Hmk

    6:38 PM - 26 May 2020
    • 136 Retweets
    • 252 Likes
    • 🦊kumavis🐙 is hiring js security folks د. عدي عصام زارع Becky Glenn Zachary Larson Letters and Numbers Sweety Gabon HellomynameisSarah KAFKA EVERYWHERE Bob
    21 replies 136 retweets 252 likes
      1. New conversation
      2. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        The "closed" variant is the Veesler Lab cryo-EM structure (https://www.biorxiv.org/content/10.1101/2020.02.19.956581v1.full …). The "open" variant is the SWISS-MODEL simulated spike protein structure (https://swissmodel.expasy.org/repository/species/26970492 …). I did the ACE2 docking myself, before we had binding data of pocket.

        2 replies 23 retweets 44 likes
        Show this thread
      3. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Here is PDB structure 6WPT, showing a truncated antibody (just the antigen-binding fragment, or Fab, in orange) bound to the spike protein (teal; with one of the trimers in "open" conformation), with the "open" conformation spike bound to ACE2 (red)pic.twitter.com/dFWVjNJ6qW

        1 reply 22 retweets 34 likes
        Show this thread
      4. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Here are the same structures as above, with an overlay this of an entire antibody (PDB ID 6C6Z against MERS-CoV) so you can visualize how big the spike protein is compared to ACE2 and an antibody.pic.twitter.com/kJfYmf8chX

        2 replies 21 retweets 32 likes
        Show this thread
      5. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Now, imagine that you have 1000 of these spikes on each virion, and that any one of the spikes has 3 components as part of a "trimer," where one of the chains can "open" up and bind to ACE2. ACE2 is a sophisticated cloaking and immune evasion mechanism, by virtue of this.

        3 replies 19 retweets 38 likes
        Show this thread
      6. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Furthermore, see all those little sugar molecules? I've colored them yellow here. These are sugars that the virus incorporates into its protein chain, which change the surface behavior of the virus. Without the sugars, your immune response will not be the same towards the spike.pic.twitter.com/4K9dpZl1EG

        2 replies 27 retweets 44 likes
        Show this thread
      7. End of conversation
      1. New conversation
      2. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Ligandal peptide nanoscaffolds are designed to interfere with ACE2-spike binding, while also promoting a strong immune response against the correct receptor-binding domain component for antibody generation. This means that you can give the nano-scaffold before or after infection.

        2 replies 10 retweets 27 likes
        Show this thread
      3. Andre Watson  🧬‏ @nanogenomic 26 May 2020

        Andre Watson  🧬 Retweeted Andre Watson  🧬

        https://twitter.com/nanogenomic/status/1265366397179228160?s=20 …

        Andre Watson  🧬 added,

        Andre Watson  🧬 @nanogenomic
        Ligandal nano-scaffolds will block the virus from binding to ACE2, act as adjuvants to other vaccines, present epitopes for correct B cell receptor and antibody formation, and exhibit T cell receptor epitopes for key immunogenic responses. This is just the start of what we do. pic.twitter.com/h73pp0Bbm7
        Show this thread
        1 reply 7 retweets 15 likes
        Show this thread
      4. Show replies
      1. New conversation
      2. Arizona Sage‏ @ArizonaSage60 26 May 2020
        Replying to @nanogenomic

        Wasn't there a Fantastic Four movie that looked like this?

        1 reply 0 retweets 1 like
      3. Andre Watson  🧬‏ @nanogenomic 26 May 2020
        Replying to @ArizonaSage60

        pic.twitter.com/VbAQxz4yY3

        1 reply 0 retweets 1 like
      4. Show replies
      1. New conversation
      2.  💜 Dr Able Lawrence MD DM 🦉周天堂‏ @abledoc 26 May 2020
        Replying to @nanogenomic

        The biggest problem with the decoy strategy is that it should probably be given during the early infection phase, which is not practical. The vaccine wins out. By the time patient is in hospital, better target downstream effects.

        2 replies 2 retweets 3 likes
      3. Andre Watson  🧬‏ @nanogenomic 26 May 2020
        Replying to @abledoc

        Whatever you say.

        1 reply 1 retweet 2 likes
      4. Show replies

    Loading seems to be taking a while.

    Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

      Promoted Tweet

      false

      • © 2022 Twitter
      • About
      • Help Center
      • Terms
      • Privacy policy
      • Cookies
      • Ads info